Results 171 to 180 of about 1,017,685 (306)

Multifunctional Manganese Oxide Nanocomposite Hydrogel With Synergistic Reactive Oxygen Species‐Scavenging, Oxygen‐Generating, Immunomodulatory, and Photothermal Antimicrobial Activities for Enhanced Diabetic Wound Healing

Advanced Science, EarlyView.
CFP/PC@MnO2 hydrogel integrates ROS scavenging, oxygen delivery, oxidative stress reduction, immunomodulation, and photothermal antibacterial properties. The incorporation of PC@MnO2 NPs endows the hydrogel with multiple functional advantages tailored to the pathological microenvironment of diabetic wounds, including efficient ROS clearance, mitigation
Zhi Xu, Xiaodong Luo, Jingxian Wu, Chaoyang Huang, Zhuoying Yang, Yixiang HePeng, Bosong Zhou, Xiang Li, Ruiyuan Liu, Xu Wu   +9 more
wiley   +1 more source

Pathogenesis of Pulmonary Artery Remodeling: TGF-Beta Signaling and Inhibin Subunit Beta A in Group 1 and 2 Pulmonary Hypertension. [PDF]

Arterioscler Thromb Vasc Biol
Yamada Y, Satoh T, Yaoita N, Yamada K, Chiba N, Komaru K, Nochioka K, Yamamoto S, Sato H, Kikuchi N, Nakata T, Sunamura S, Inoue T, Hayashi H, Suzuki H, Tatebe S, Takahama H, Oishi H, Miyata S, Okada Y, Yasuda S.   +20 more
europepmc   +1 more source

TGF-beta signal transduction: biology, function and therapy for diseases. [PDF]

Mol Biomed, 2022
Tie Y, Tang F, Peng D, Zhang Y, Shi H.
europepmc   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Latent transforming growth factor binding protein-2 (LTBP2), an IPF biomarker of clinical decline, promotes TGF-beta signaling and lung fibrosis in mice. [PDF]

Am J Respir Cell Mol Biol
Bodmer NK, Choudhury M, Mirza H, Pradhan S, Yin Y, Mecham RP, Brody SL, Ornitz DM, Koenitzer JR.   +8 more
europepmc   +1 more source

Correlation Between Maternal Age and Cytokine (IL-6 and TGF-Beta) Levels in Colostrum. [PDF]

Cureus, 2023
Shivani, Bhattacharya S, Ali W, Ghildiyal A.   +3 more
europepmc   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

miR-375-3p/STX6 Exacerbates Atherosclerosis by Promoting Endothelial Cell Senescence via Activation of TGF-Beta Signals. [PDF]

Aging Cell
Zhu Y, Liu Z, Wan Y, Ding S, Liu J, Wu A, Dai X, Zhou J, Li X, Gong X, Liu M, Tian XL.   +11 more
europepmc   +1 more source

Cancer-associated fibroblasts drive CXCL13 production in activated T cells via TGF-beta. [PDF]

Front Immunol, 2023
O'Connor RA, Martinez BR, Koppensteiner L, Mathieson L, Akram AR.   +4 more
europepmc   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source