Results 171 to 180 of about 270,164 (307)

Pathogenesis of Pulmonary Artery Remodeling: TGF-Beta Signaling and Inhibin Subunit Beta A in Group 1 and 2 Pulmonary Hypertension. [PDF]

Arterioscler Thromb Vasc Biol
Yamada Y, Satoh T, Yaoita N, Yamada K, Chiba N, Komaru K, Nochioka K, Yamamoto S, Sato H, Kikuchi N, Nakata T, Sunamura S, Inoue T, Hayashi H, Suzuki H, Tatebe S, Takahama H, Oishi H, Miyata S, Okada Y, Yasuda S.   +20 more
europepmc   +1 more source

Correlation Between Maternal Age and Cytokine (IL-6 and TGF-Beta) Levels in Colostrum. [PDF]

Cureus, 2023
Shivani, Bhattacharya S, Ali W, Ghildiyal A.   +3 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Editorial: The role of TGF-beta superfamily members in immune homeostasis and disease. [PDF]

Front Immunol
Nieuwenhuizen NE, Eleftherianos I, Kraj PJ, Semitekolou M.   +3 more
europepmc   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Targeting noncanonical TGF-beta signaling: inhibition effects on the human keloid fibroblast transcriptome. [PDF]

Itch (Phila)
Morningstar J, Sivadas A, Romeo M, Vaena S, Valdebran M, Kwatra SG, Norris RA, Beck TC.   +7 more
europepmc   +1 more source

Cancer-associated fibroblasts drive CXCL13 production in activated T cells via TGF-beta. [PDF]

Front Immunol, 2023
O'Connor RA, Martinez BR, Koppensteiner L, Mathieson L, Akram AR.   +4 more
europepmc   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

miR-375-3p/STX6 Exacerbates Atherosclerosis by Promoting Endothelial Cell Senescence via Activation of TGF-Beta Signals. [PDF]

Aging Cell
Zhu Y, Liu Z, Wan Y, Ding S, Liu J, Wu A, Dai X, Zhou J, Li X, Gong X, Liu M, Tian XL.   +11 more
europepmc   +1 more source

PDIA6, which is regulated by TRPM2-AS/miR-424-5p axis, promotes endometrial cancer progression via TGF-beta pathway. [PDF]

Cell Death Dis, 2023
Wang P, Zhang T, Jiang N, Wang K, Feng L, Liu T, Yang X.   +6 more
europepmc   +1 more source