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Sending out molecules from the TGN
Current Opinion in Cell Biology, 2021The sorting of secreted cargo proteins and their export from the trans-Golgi network (TGN) remains an enigma in the field of membrane trafficking; although the sorting mechanisms of many transmembrane proteins have been well described. The sorting of secreted proteins at the TGN is crucial for the release of signaling factors, as well as extracellular ...
Bulat R, Ramazanov +2 more
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Journal of Cell Science, 2023
ABSTRACT Clathrin-mediated vesicle trafficking plays central roles in post-Golgi transport. In yeast (Saccharomyces cerevisiae), the AP-1 complex and GGA adaptors are predicted to generate distinct transport vesicles at the trans-Golgi network (TGN), and the epsin-related proteins Ent3p and Ent5p (collectively Ent3p/5p) act as ...
Makoto Nagano +5 more
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ABSTRACT Clathrin-mediated vesicle trafficking plays central roles in post-Golgi transport. In yeast (Saccharomyces cerevisiae), the AP-1 complex and GGA adaptors are predicted to generate distinct transport vesicles at the trans-Golgi network (TGN), and the epsin-related proteins Ent3p and Ent5p (collectively Ent3p/5p) act as ...
Makoto Nagano +5 more
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Plant TGNs: dynamics and physiological functions
Histochemistry and Cell Biology, 2013In all eukaryotic cells, a membrane trafficking system connects the post-Golgi organelles, including the trans-Golgi network (TGN), endosomes, and vacuoles. This complex network plays critical roles in several higher-order functions in multicellular organisms.
Tomohiro, Uemura, Akihiko, Nakano
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Golgi apparatus and TGN during endocytosis
Histochemistry and Cell Biology, 2002Wheat germ agglutinin labelled with horseradish peroxidase (WGA) was used for analyses of endosomal compartments and Golgi apparatus in HepG(2) hepatoma cells during early and late periods of endocytosis. WGA was rapidly transferred into the Golgi region. Transport of internalised WGA into the Golgi apparatus could be classified in three stages.
Monika, Vetterlein +3 more
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2010
The term “trans Golgi network” (TGN) is used for complex and dynamic membrane compartments located at the trans Golgi side (cf. Figs. 33–35, 48). Because of its complexity and highly dynamic behaviour, the TGN belongs to the most interesting but also enigmatic and challenging structures of the cell.
Margit Pavelka, Jürgen Roth
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The term “trans Golgi network” (TGN) is used for complex and dynamic membrane compartments located at the trans Golgi side (cf. Figs. 33–35, 48). Because of its complexity and highly dynamic behaviour, the TGN belongs to the most interesting but also enigmatic and challenging structures of the cell.
Margit Pavelka, Jürgen Roth
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Retrograde endosome-to-TGN transport
2009Eukaryotic cells are characterized by the existence of many membranebound organelles with each having a unique structural composition and carrying out specific cellular functions. Many of these organelles are parts of the secretory and endocytic pathways and are integrated by dynamic interorganellar membrane trafficking events.
Lei Lu, Wanjin Hong
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The Formation of TGN-to-Plasma-Membrane Transport Carriers
Annual Review of Cell and Developmental Biology, 2006In the trans-Golgi network (TGN), proteins are sorted for transport to the endosomes, plasma membrane, preceding Golgi cisternae, and endoplasmic reticulum. The formation of clathrin-coated vesicles for transport to the endosomes and of COP-I-coated vesicles for retrograde trafficking is fairly well characterized at the molecular level.
Frédéric, Bard, Vivek, Malhotra
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Golgi Apparatus and TGN — Structural Considerations
2010The pioneering work of Rambourg and colleagues laid the foundations for what is nowadays known as the trans Golgi network (TGN). As early as 1969, he reported an extensive system of anastomosing tubules at the trans-side of the Golgi apparatus of intestinal absorptive cells, named the trans-tubular network of the Golgi apparatus.
Margit Pavelka, Jürgen Roth
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Dynamic retention of TGN membrane proteins in Saccharomyces cerevisiae
Trends in Cell Biology, 1993In a secretory pathway organelle like the Golgi complex, resident proteins are retained in the face of substantial protein flux to subsequent destinations. Recently, molecular genetic strategies have been used to study membrane protein retention in a compartment of the yeast Saccharomyces cerevisiae that is analogous to the trans Golgi network (TGN) of
K, Wilsbach, G S, Payne
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Golgi Apparatus and TGN — Secretion and Endocytosis
2010The Golgi apparatus is not only a pivotal organelle and main crossroads in the secretory pathway, but also has a central role during endocytosis (cf. Fig. 48). Studies with multiple cell types showed, that distinct endocytic routes exist from the plasma membrane to the Golgi apparatus, involving early and late endosomal compartments.
Margit Pavelka, Jürgen Roth
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