Results 21 to 30 of about 44,760 (150)

Phosphoinositide-mediated clathrin adaptor progression at the trans-Golgi network. [PDF]

, 2012
Clathrin-coated vesicles mediate endocytosis and transport between the trans-Golgi network (TGN) and endosomes in eukaryotic cells. Clathrin adaptors play central roles in coat assembly, interacting with clathrin, cargo and membranes.
Costaguta, Giancarlo, Daboussi, Lydia, Payne, Gregory S   +2 more
core   +1 more source

Student's $t$-test for scale mixture errors

, 2006
Generalized t-tests are constructed under weaker than normal conditions. In the first part of this paper we assume only the symmetry (around zero) of the error distribution (i). In the second part we assume that the error distribution is a Gaussian scale
Székely, Gábor J.
core   +2 more sources

On a problem in eigenvalue perturbation theory [PDF]

, 2015
We consider additive perturbations of the type $K_t=K_0+tW$, $t\in [0,1]$, where $K_0$ and $W$ are self-adjoint operators in a separable Hilbert space $\mathcal{H}$ and $W$ is bounded.
Gesztesy, Fritz, Naboko, Sergey N., Nichols, Roger   +2 more
core   +1 more source

Localization of SMAP2 to the TGN and its Function in the Regulation of TGN Protein Transport

Cell Structure and Function, 2011
SMAP2 is an Arf GTPase-activating protein that is located and functions on early endosome membranes. In the present study, the trans-Golgi network (TGN) was verified as an additional site of SMAP2 localization based on its co-localization with various TGN-marker proteins.
Tomo, Funaki, Shunsuke, Kon, Roger E, Ronn, Yuji, Henmi, Yuka, Kobayashi, Toshio, Watanabe, Keiko, Nakayama, Kenji, Tanabe, Masanobu, Satake   +8 more
openaire   +3 more sources

Distinct role of TGN-resident clathrin adaptors for Rab5 activation in the TGN-endosome trafficking pathway

, 2023
Abstract Clathrin-mediated vesicle trafficking plays central roles in the post-Golgi transport pathways from the trans -Golgi network (TGN) to endosomes. In yeast, two clathrin adaptors – AP-1 complex and GGA proteins (GGAs) – are predicted to generate distinct transport vesicles at
Makoto Nagano, Kaito Aoshima, Hiroki Shimamura, Daria Elisabeth Siekhaus, Junko Y. Toshima, Jiro Toshima   +5 more
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Estimating the summertime tropospheric ozone distribution over North America through assimilation of observations from the Tropospheric Emission Spectrometer [PDF]

, 2008
We assimilate ozone and CO retrievals from the Tropospheric Emission Spectrometer (TES) for July and August 2006 into the GEOS-Chem and AM2-Chem models.
A. M. Thompson, Beer, Benkovitz, Bey, Bowman, Bowman, Brasseur, Chai, Clark, Clough, Cooper, Cooper, D. B. A. Jones, D. W. Tarasick, Duncan, Duncan, Elbern, Fiore, Fishman, Geer, GFDL GAMDT, Horowitz, Horowitz, Hudman, Hudman, J. C. Witte, Jones, Jourdain, K. W. Bowman, Khattatov, Kulawik, L. W. Horowitz, Lahoz, Lamarque, Lawrence, Li, Liang, Logan, Logan, Luo, Luo, M. Parrington, McLinden, Munro, Ménard, Nassar, Oltmans, Osterman, Pickering, Pierce, Price, Price, Randel, Rodgers, Sauvage, Segers, Stevenson, Tarasick, Tellmann, TES Science Team, Thompson, Thompson, Tie, Wild, Worden, Yevich   +65 more
core   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Egorov's theorem for transversally elliptic operators on foliated manifolds and noncommutative geodesic flow

, 2004
The main result of the paper is Egorov's theorem for transversally elliptic operators on compact foliated manifolds. This theorem is applied to describe the noncommutative geodesic flow in noncommutative geometry of Riemannian foliations.Comment: 23 ...
A. Connes, A. Connes, A. Connes, A. Lichnerowicz, A. Lichnerowicz, B. L. Reinhart, C. Anantharaman-Delaroche, F. Trèves, I. Satake, J. Block, J. Duistermaat, Ju. V. Egorov, L. Hörmander, M. Taylor, O’Neill, P. Libermann, P. Molino, Ping Xu, R. S. Palais, R. T. Seeley, T. Fack, T. Kawasaki, T. Kawasaki, V. Guillemin, W. Chen, Yu. A. Kordyukov, Yu. A. Kordyukov, Yuri A. Kordyukov   +27 more
core   +1 more source