Results 31 to 40 of about 44,760 (150)
The role of clathrin in post-golgi trafficking in toxoplasma gondii [PDF]
, 2013 Apicomplexan parasites are single eukaryotic cells with a highly polarised secretory system that contains unique secretory organelles (micronemes and rhoptries) that are required for host cell invasion.
Ferguson, D.J.P. +3 more
core +4 more sources
Quasi‐Random Nanostructured Substrates for Enhancing Light Outcoupling in OLEDs
Advanced Optical Materials, EarlyView.ABSTRACT Organic light–emitting diodes (OLEDs) suffer from low light outcoupling efficiency, with much of the generated light trapped within the device. To address this issue, we present a scalable, maskless, polymer‐free strategy for fabricating quasi‐random external nanowire (ENW) and internal nanocorrugation (INC) structures directly on glass ...
Mehdi Zarei +8 more
wiley +1 more source
The SNARE machinery is involved in apical plasma membrane trafficking in MDCK cells. [PDF]
, 1998 We have investigated the controversial involvement of components of the SNARE (soluble N-ethyl maleimide-sensitive factor [NSF] attachment protein [SNAP] receptor) machinery in membrane traffic to the apical plasma membrane of polarized epithelial (MDCK)
Chapin, SJ +6 more
core
Domains of the TGN: Coats, Tethers and G Proteins [PDF]
Traffic, 2004 The trans‐Golgi network is the major sorting compartment of the secretory pathway for protein, lipid and membrane traffic. There is a constant flow of membrane and cargo to and from this compartment. Evidence is emerging that the trans‐Golgi network has multiple biochemically and functionally distinct subdomains, each of which contributes to the ...
Gleeson, Paul A. +3 more
openaire +3 more sources
Advanced Science, EarlyView.A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li +6 more
wiley +1 more source
An early secretory pathway mediated by GNOM-LIKE 1 and GNOM is essential for basal polarity establishment in Arabidopsis thaliana [PDF]
, 2015 Spatial regulation of the plant hormone indole-3-acetic acid (IAA, or auxin) is essential for plant development. Auxin gradient establishment is mediated by polarly localized auxin transporters, including PIN-FORMED (PIN) proteins. Their localization and
Doyle, Siamsa M +10 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis +5 more
wiley +1 more source
LOT regulates TGN biogenesis and Golgi structure in plants [PDF]
Plant Signaling & Behavior, 2019 Trans-Golgi Network (TGN) is an essential organelle in eukaryotic cells. It acts not only as the sorting station of trafficking cargoes, but also as a signaling hub. In plant cells, TGN simultaneously takes the role of early endosome (EE) and contributes to the endocytic recycling.
Peng-Fei Jia +3 more
openaire +2 more sources
British Journal of Clinical Pharmacology, EarlyView.Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt +13 more
wiley +1 more source
Making Two out of One: Kinesin Motors Driving Plant Cell Division
Cytoskeleton, EarlyView.ABSTRACT The Kinesin superfamily of microtubule dependent motors is present in all eukaryotes. Not all of the subfamilies are represented in all kingdoms, and the ones that are do not always show conserved functions. Tight control of the cytoskeleton is essential for proper progression and completion of mitosis and cytokinesis, and key functions are ...
Choy Kriechbaum, Sabine Müller
wiley +1 more source