Results 41 to 50 of about 44,760 (150)

Meeting of conventional and unconventional pathways at the TGN [PDF]

Communicative & Integrative Biology, 2009
The biosynthetic pathway allows the transport of newly synthesized proteins to the TGN via the reticulum endoplasmic and Golgi apparatus. However, many large particles reach the TGN by unconventional means. For instance, Herpes simplex virus type 1(HSV-1) capsids assemble within the nucleus, bud into the perinuclear space, fuse with the outer nuclear ...
Gaudeline, Rémillard-Labrosse, Roger, Lippé   +1 more
openaire   +2 more sources

Migrasomes, Matrix‐Bound Nanovesicles, and More: Messengers in the Matrix

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) and particles (EPs) are diverse micro‐ and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix‐bound or matrix‐associated EVs and EPs (MEVPs) have been unclear, largely due to
Anna V. Kolesov, Natalie Reitz, Marley Dewey, Colin L. Hisey   +3 more
wiley   +1 more source

PI4K2β/AP-1-Based TGN-Endosomal Sorting Regulates Wnt Signaling [PDF]

Current Biology, 2013
Endosomal membrane traffic serves crucial roles in cell physiology, signaling, and development. Sorting between endosomes and the trans-Golgi network (TGN) is regulated among other factors by the adaptor AP-1, an essential component of multicellular organisms.
Wieffer, Marnix, Uhalte, Elena Cibrian, Posor, York, Otten, Cecile, Branz, Katharina, Schuetz, Irene, Moessinger, Julia, Schu, Peter, Abdelilah-Seyfried, Salim, Krauss, Michael, Haucke, Volker   +10 more
openaire   +3 more sources

Reduction in Synaptic Vesicle Protein Abundance but Increased Amounts of Nsg2 and Lpcat1 in Cerebral Cortices Without the Endosomal SNARE Proteins Vti1a and Vti1b

PROTEOMICS, EarlyView.
ABSTRACT Absence of the endosomal SNAREs vti1a and vti1b results in perinatal death and severe neuronal phenotypes in mice, while lack of one of these proteins results in minor phenotypes. Proteomic differences were investigated to obtain a deeper insight into processes in which vti1a and vti1b are involved.
Julia Gottschalk, Katharina Kotschnew, Julia Hahn, Thomas Patschkowski, Gabriele von Fischer von Mollard   +4 more
wiley   +1 more source

Prey DNA Detection in Lycosid Spiders Is Primarily Influenced by Time Since Feeding and Primer Choice

Entomologia Experimentalis et Applicata, EarlyView.
Gut content analysis using DNA metabarcoding has improved understanding of predator–prey interactions involving spiders. We tested how starvation before feeding, time since feeding, spider size, and the presence of egg sacs or spiderlings affect prey DNA detection in Lycosidae.
Jeffery Marker, Denis Lafage, Eva Bergman, Ann Erlandsson   +3 more
wiley   +1 more source

Rab7 palmitoylation is required for efficient endosome-to-TGN trafficking [PDF]

Journal of Cell Science, 2017
ABSTRACT Retromer is a multimeric protein complex that mediates endosome-to-trans-Golgi network (TGN) and endosome-to-plasma membrane trafficking of integral membrane proteins. Dysfunction of this complex has been linked to Alzheimer's disease and Parkinson's disease. The recruitment of retromer to endosomes is regulated by Rab7 (also
Graziana Modica, Olga Skorobogata, Etienne Sauvageau, Adriano Vissa, Christopher M. Yip, Peter K. Kim, Hugo Wurtele, Stephane Lefrancois   +7 more
openaire   +3 more sources

RNF13 is a previously undescribed interactor of iduronate 2‐sulfatase that modifies its glycosylation and maturation

The FEBS Journal, EarlyView.
Iduronate 2‐sulfatase (IDS; purple) is expressed as a precursor protein that goes through multiple steps of maturation, modification, and trafficking to become an active lysosomal enzyme that degrades glycosaminoglycans. Our study shows that the transmembrane ubiquitin ligases RNF13 (orange) and RNF167 (pink) heterodimerize, affecting IDS intracellular
Valérie C. Cabana, Antoine Y. Bouchard, Audrey M. Sénécal, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Do Psychosocial Resources Mitigate the Impact of Adverse Childhood Experiences in Oral Health‐Related Quality of Life Among Adolescents

International Journal of Paediatric Dentistry, EarlyView.
ABSTRACT Background Adverse childhood experiences (ACEs) are associated with poorer general and oral health outcomes, but the psychosocial mechanisms underlying these associations remain unclear. Aim The aim of this study is to assess whether perceived social support and sense of coherence (SOC) moderate the association between ACEs and oral health ...
Thaís Gioda Noronha‐Ramos, Jessica Klöckner Knorst, Thiago Machado Ardenghi, Bruno Emmanuelli, Bruna Brondani, Fernanda Tomazoni   +5 more
wiley   +1 more source

Ligand‐induced ubiquitination regulates endocytosis and homeostasis of the ERECTA receptor kinase for stomatal development

New Phytologist, EarlyView.
Summary Stomatal patterning on the plant epidermis is regulated by the ERECTA family of leucine‐rich repeat receptor kinases (LRR‐RKs). While ubiquitination has emerged as a key regulatory mechanism for the endocytosis of receptor kinases, the precise molecular connections among ERECTA ubiquitination, endocytosis, and its biological functions remain ...
Liangliang Chen, Minh Huy Vu, Pengfei Bai, Alicia M. Cochran, Crystal F. Ying, Keiko U. Torii   +5 more
wiley   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source