Results 31 to 40 of about 43,670 (169)

Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation.

JCI Insight, 2019
Th1 and Th17 are important in the pathogenesis of autoimmune diseases and they depend on glycolysis as a source of energy. T cell antigen receptor signaling phosphorylates a serine/threonine kinase, calcium/calmodulin-dependent protein kinase IV (CaMK4),
M. Kono, Kayaho Maeda, Irina Stocton-Gavanescu, Wenliang Pan, M. Umeda, E. Katsuyama, Catalina Burbano, S. Y. K. Orite, M. Vukelic, M. Tsokos, N. Yoshida, G. Tsokos   +11 more
semanticscholar   +1 more source

From Design to Management: Exploring BIM’s Role across Project Lifecycles, Dimensions, Data, and Uses, with Emphasis on Facility Management

Buildings
The importance of Building Information Modelling (BIM) in construction and facility operation is unquestionable, but there is a clear discrepancy between the data included in as-built BIM models and the expected use specified by customers. This disparity
Esraa J. Altwassi, Emre Aysu, Kerem Ercoskun, Abeer Abu Raed   +3 more
doaj   +1 more source

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones

Journal of Experimental Medicine, 1989
A cytokine synthesis inhibitory factor (CSIF) is secreted by Th2 clones in response to Con A or antigen stimulation, but is absent in supernatants from Con A-induced Th1 clones.
D. Fiorentino, M. Bond, T. Mosmann
semanticscholar   +1 more source

Trends, Problems, and Solutions from Point Cloud via Non-Uniform Rational Basis Spline to Building Information Modelling: Bibliometric and Systematic Study

Buildings
Building Information Modelling (BIM) has found applications not only in the planning and designing of new buildings but also in project monitoring, record-keeping, and analyses of existing structures.
Dina Stober, Nikolina Raguz-Lucic
doaj   +1 more source

Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation

Journal of Experimental Medicine, 2018
Eosinophils are predominantly known for their contribution to allergy. Here, we have examined the function and regulation of gastrointestinal eosinophils in the steady-state and during infection with Helicobacter pylori or Citrobacter rodentium.
I. Arnold, Mariela Artola-Borán, P. Tallón de Lara, Andreas Kyburz, C. Taube, K. Ottemann, M. van den Broek, S. Yousefi, H. Simon, A. Müller   +9 more
semanticscholar   +1 more source

A Study on the Effect of Dynamic Photovoltaic Shading Devices on Energy Consumption and Daylighting of an Office Building

Buildings
Photovoltaic shading devices (PVSDs) have the dual function of providing shade and generating electricity, which can reduce building energy consumption and improve indoor daylighting levels.
Yan Jiang, Zongxin Qi, Shenglin Ran, Qingsong Ma   +3 more
doaj   +1 more source

Th1 effector T cells selectively orchestrate cardiac fibrosis in nonischemic heart failure

Journal of Experimental Medicine, 2017
Despite emerging data indicating a role for T cells in profibrotic cardiac repair and healing after ischemia, little is known about whether T cells directly impact cardiac fibroblasts (CFBs) to promote cardiac fibrosis (CF) in nonischemic heart failure ...
T. Nevers, Ane M. Salvador, Francisco E. Velázquez, Njabulo Ngwenyama, F. Carrillo-Salinas, M. Aronovitz, Robert M. Blanton, P. Alcaide   +7 more
semanticscholar   +1 more source

Comparative analysis of design models for concrete corbels

Revista IBRACON de Estruturas e Materiais
The main objective of this paper is performing a comparative analysis of some design models for precast concrete corbels. For this, it was analyzed design models from Brazilian (NBR 9062) and European (EUROCODE 2) Codes and a US design handbook (PCI ...
D. L. Araújo, A. P. Silva Neto, F. A. Lobo, M. K. El Debs   +3 more
doaj   +1 more source

The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination

Journal of Experimental Medicine, 2017
Type 1 T helper (Th1) cells play a critical role in host defense against intracellular pathogens and in autoimmune diseases by producing a key inflammatory cytokine interferon (IFN)–&ggr;; some Th1 cells can also be antiinflammatory through producing IL ...
Fang Yu, Suveena Sharma, Dragana Jankovic, R. Gurram, Pan Su, Gangqing Hu, Rao Li, S. Rieder, K. Zhao, Bing Sun, Jinfang Zhu   +10 more
semanticscholar   +1 more source

Epigenetic silencing of Th1 type chemokines shapes tumor immunity and immunotherapy

Nature, 2015
Epigenetic silencing including histone modifications and DNA methylation is an important tumorigenic mechanism. However, its role in cancer immunopathology and immunotherapy is poorly understood.
D. Peng, Ilona Kryczek, N. Nagarsheth, Lili Zhao, Shuang Wei, Weimin Wang, Yuqing Sun, Ende Zhao, Linda Vatan, Wojciech Szeliga, J. Kotarski, R. Tarkowski, Y. Dou, Kathleen R. Cho, S. Hensley-Alford, A. Munkarah, Rebecca J Liu, W. Zou   +17 more
semanticscholar   +1 more source