Results 11 to 20 of about 43,670 (169)

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

Cell, 2018
SUMMARY Activated T cells differentiate into functional subsets with distinct metabolic programs. Glutaminase (GLS) converts glutamine to glutamate to support the tricarboxylic acid cycle and redox and epigenetic reactions.
Marc O. Johnson, Marc O. Johnson, Melissa M. Wolf, M. Madden, G. Andrejeva, Ayaka Sugiura, Diana C. Contreras, Damian Maseda, Maria Liberti, Katelyn Paz, Rigel J. Kishton, Matthew E Johnson, A. A. Cubas, Pingsheng Wu, Gongbo Li, Yongliang Zhang, D. C. Newcomb, Andrew D. Wells, N. Restifo, W. Rathmell, W. Rathmell, J. Locasale, M. Davila, Bruce R. Blazar, J. Rathmell, J. Rathmell   +25 more
semanticscholar   +1 more source

MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile

Cytokine, 2018
HIGHLIGHTSMERS is caused by a single‐stranded RNA virus named MERS‐corona virus.Infection with MERS‐CoV elicits a type‐I and type‐II interferon response.MERS‐CoV infected patients show a prominent Th1 and Th17 cytokine profile.MERS‐CoV infection induces ...
Waleed H. Mahallawi, O. Khabour, Qibo Zhang, Hatim Makhdoum, B. Suliman   +4 more
semanticscholar   +1 more source

Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis

Nature Communications, 2018
T-cells are crucial in maintanence of intestinal homeostasis, however, it is still unclear how microbiota metabolites regulate T-effector cells. Here we show gut microbiota-derived short-chain fatty acids (SCFAs) promote microbiota antigen-specific Th1 ...
Mingming Sun, Wei Wu, Liang Chen, Wenjing Yang, Xiangsheng Huang, Caiyun Ma, Feidi Chen, Yi Xiao, Ye Zhao, Chunyan Ma, Suxia Yao, Victor H. Carpio, Sara M. Dann, Qihong Zhao, Zhanju Liu, Y. Cong   +15 more
semanticscholar   +1 more source

A novel transcription factor, T-bet, directs Th1 lineage commitment.

Cell, 2000
Naive T helper cells differentiate into two subsets, Th1 and Th2, each with distinct functions and cytokine profiles. Here, we report the isolation of T-bet, a Th1-specific T box transcription factor that controls the expression of the hallmark Th1 ...
S. Szabo, Sean T. Kim, G. Costa, Xiankui Zhang, C. Fathman, L. Glimcher   +5 more
semanticscholar   +1 more source

Microbiota Metabolite Butyrate Differentially Regulates Th1 and Th17 Cells' Differentiation and Function in Induction of Colitis.

Inflammatory Bowel Diseases, 2019
BACKGROUND How the gut microbiota regulates intestinal homeostasis is not completely clear. Gut microbiota metabolite short-chain fatty acids (SCFAs) have been reported to regulate T-cell differentiation.
Liang Chen, Mingming Sun, Wei Wu, Wenjing Yang, Xiangsheng Huang, Yi Xiao, Chunyan Ma, Leiqi Xu, Suxia Yao, Zhanju Liu, Y. Cong   +10 more
semanticscholar   +1 more source

FE Model Updating of Continuous Beam Bridge Based on Response Surface Method

Buildings
In this paper, A high-order response surface method is proposed for finite element model updating of continuous beam bridges. Firstly, based on visual inspection and environmental vibration testing, the peak picking (PP) method and random subspace ...
Fang Dong, Zhongqi Shi, Rumian Zhong, Nan Jin   +3 more
doaj   +1 more source

Building Energy Governance: Statutes and Guides on Retro-Commissioning in China and the United States

Buildings
Reducing building energy use, a linchpin of climate change mitigation, is a daunting challenge across the world. Gaining increasing attention, retro-commissioning (RCx) is a systematic process that can improve building energy performance.
Savannah Y. T. Lai, Joseph H. K. Lai, Philip Y. L. Wong, David Edwards   +3 more
doaj   +1 more source

Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation

Science, 2017
Gut reasons to brush your teeth Some gut conditions, such as inflammatory bowel disease (IBD), ulcerative colitis, and Crohn's disease (CD), are associated with imbalances in the gut microbe community.
K. Atarashi, W. Suda, Chengwei Luo, T. Kawaguchi, Iori Motoo, S. Narushima, Yuya Kiguchi, Keiko Yasuma, E. Watanabe, Takeshi Tanoue, Christoph A. Thaiss, Mayuko Sato, K. Toyooka, H. Said, H. Yamagami, S. Rice, D. Gevers, Ryan C. Johnson, J. Segre, Kong Chen, J. Kolls, E. Elinav, H. Morita, R. Xavier, M. Hattori, K. Honda   +25 more
semanticscholar   +1 more source

Enhancing Volumetric Stability of Metakaolin-Based Geopolymer Composites with Organic Modifiers WER and SCA

Buildings
Shrinkage during hardening and curing is one of the largest challenges for the widespread application of metakaolin-based geopolymers (MKGs). To solve this problem, a silane coupling agent (SCA) and waterborne epoxy resin (WER) were used to synthesize ...
Mo Zhang, Yongquan Zang, Lingyan Shan
doaj   +1 more source

Public Memory, Architectural Language, and Its Configurational Relationship in the Memorial Museum: A Case Study of the War Memorial of Korea Using Space Syntax and Movement Tracking

Buildings
Memorial museums serve as a record of the past and provide evidence of the past; moreover, they are a place for remembering the past and healing the present.
Jae Hong Lee
doaj   +1 more source