Results 1 to 10 of about 43,670 (169)
Polysaccharides regulate Th1/Th2 balance: A new strategy for tumor immunotherapy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023 T helper (Th) cells have received extensive attention owing to their indispensable roles in anti-tumor immune responses. Th1 and Th2 cells are two key subsets of Th cells that exist in relative equilibrium through the secretion of cytokines that suppress
Qihang Shang +5 more
semanticscholar +1 more source
The emerging role of Th1 cells in atherosclerosis and its implications for therapy
Frontiers in Immunology, 2023 Atherosclerosis is a chronic progressive inflammatory disease of the large and medium-sized artery walls. The molecular mechanisms regulating the onset and progression of atherosclerosis remain unclear.
Jiaojiao Chen +7 more
semanticscholar +1 more source
Distinct spatial and temporal roles for Th1, Th2, and Th17 cells in asthma
Frontiers in Immunology, 2022 Immune response in the asthmatic respiratory tract is mainly driven by CD4+ T helper (Th) cells, represented by Th1, Th2, and Th17 cells, especially Th2 cells.
Weihan Luo +3 more
semanticscholar +1 more source
Autocrine Vitamin D-signaling switches off pro-inflammatory programs of Th1 cells
Nature Immunology, 2021 The molecular mechanisms governing orderly shutdown and retraction of CD4+ type 1 helper T (TH1) cell responses remain poorly understood. Here we show that complement triggers contraction of TH1 responses by inducing intrinsic expression of the vitamin D
D. Chauss +28 more
semanticscholar +1 more source
Recent advances in understanding the Th1/Th2 effector choice
Faculty Reviews, 2021 For over 35 years since Mosmann and Coffman proposed the seminal “type 1 T helper (Th1)/type 2 T helper (Th2)” hypothesis in 1986, the immunological community has appreciated that naïve CD4 T cells need to make important decisions upon their activation ...
M. Butcher, Jinfang Zhu
semanticscholar +1 more source
Th2/Th1 Cytokine Imbalance Is Associated With Higher COVID-19 Risk Mortality
Frontiers in Genetics, 2021 A major component of COVID-19 severe respiratory syndrome is the patient’s immune response to the SARS-CoV-2 virus and the consequential multi-organ inflammatory response.
A. Pavel +5 more
semanticscholar +1 more source
In Vivo CD4+ T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm.
Annual Review of Immunology, 2020 The discovery of CD4+ T cell subset-defining master transcription factors and framing of the Th1/Th2 paradigm ignited the CD4+ T cell field.
Mikel Ruterbusch +3 more
semanticscholar +1 more source
Frontiers in Immunology, 2020 During pregnancy, various immune effectors and molecules participating in the immune-microenvironment establish specific maternal tolerance toward the semi-allogeneic fetus.
Wen-juan Wang +3 more
semanticscholar +1 more source
Impact of design parameters and stress-strain diagrams on the ultimate limit state of instability in reinforced concrete columns [PDF]
Revista IBRACON de Estruturas e MateriaisIn high-rise buildings, high-strength concrete (HSC) columns are often used to reduce cross-sectional dimensions while supporting high loads. However, this design decision may result in structures that are more susceptible to deformation, raising ...
Nicolle Lorrayne Domingos Guerra +1 more
doaj +1 more source
Use of nano-sized components in multilayer composite materials [PDF]
Нанотехнологии в строительствеIntroduction. In our country, the use of composite materials for creating parts and structural components in the construction industry is not as widespread as it could be.
Lybov A. Bokhoeva +5 more
doaj +1 more source