Results 151 to 160 of about 4,547,937 (252)

Th17 cell function in periodontitis

Periodontitis is a chronic inflammatory disease influenced by microbial challenges and host immune responses, with Th17 cells playing a central role in both protection and tissue destruction.
Onyeama , Uzoramaka Udodirim
core  

IL-15 Promotes Inflammatory Th17 Cells in the Intestine. [PDF]

Inflamm Bowel Dis
Hou G, Lee A, Golob JL, Grasberger H, Berinstein E, Swanson BJ, Bishu SR, Zataari ME, Khaykin V, Berinstein JA, Fry C, Nemzek J, Kamada N, Kao J, Bishu S.   +14 more
europepmc   +1 more source

Shared and Distinguishing Features of Late‐Onset Rheumatic Diseases Fulfilling Polymyalgia Rheumatica Classification Criteria

Arthritis &Rheumatology, Accepted Article.
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Kerem Abacar, Ala Altaie, Andrew Barr, Sarah L. Mackie, Kulveer Mankia, Dennis McGonagle   +5 more
wiley   +1 more source

Mast cell-derived MIF Polarizes Th17 cells to drive lung adenocarcinoma progression. [PDF]

Cancer Immunol Immunother
Peng Q, Ye X, Xu X, Song J, Yang Z, Xiao H.   +5 more
europepmc   +1 more source

Treatment‐driven peripheral blood transcriptomic remodelling and baseline predictors of ESSDAI and STAR response to B‐cell therapy in Sjögren's disease

Arthritis &Rheumatology, Accepted Article.
Objective To characterise whole‐blood transcriptomic profiles in adults with active Sjögren's disease (SjD) treated with anti‐CD20 or BlyS/BAFF inhibition, identify markers of clinical response, and define inflammatory pathways linked to non‐response. Methods Whole‐blood RNA sequencing was performed at baseline and week‐24 in participants (n=43) from a
Aimen Ibrahim, Junjie Peng, Eileen Tian, Lucia Martin‐Gutierrez, John Casement, Kyle Thompson, Wan‐Fai Ng, André van Maurik, Elizabeth C Jury, Coziana Ciurtin   +9 more
wiley   +1 more source

Itaconate and its derivatives ameliorate autoimmunity by suppressing Th17 cells via regulating mitophagy. [PDF]

Cell Commun Signal
Li F, Huang Q, Zheng N, Zhang W, Luo S, Wang R, Bathini T, Sun P, Li X, Huang X, Maj T.   +10 more
europepmc   +1 more source

Targeting Amastigote and Trypomastigote Phases: Multi‐Epitope Vaccine Strategy Against Trypanosoma cruzi

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva, Caio Patrício de Souza Sena, Davi Serradella Vieira, Magdi E. A. Zaki, Leow Chiuan Yee, Shahina Akter, Umberto Laino Fulco, Jonas Ivan Nobre Oliveira, João Firmino Rodrigues‐Neto   +8 more
wiley   +1 more source

Th17 cells favor migration and invasiveness of cervical cancer cells under hypoxia in an IGF2BP2-dependent manner. [PDF]

Int J Cancer
Gies S, Pohlers M, Tänzer T, Ampofo E, Laschke MW, Schäfer M, Kim YJ, Bohle RM, Solomayer EF, Wagner K, Empting M, Kiemer AK, Walch-Rückheim B.   +12 more
europepmc   +1 more source

A phase 1 study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of PF‐07261271 in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim There is an unmet need for more effective therapies in inflammatory bowel disease (IBD). A single drug that blocks multiple distinct pathogenic pathways may offer therapeutic benefit superior to current monotherapies. PF‐07261271, a bispecific antibody targeting both the p40 subunit of interleukin‐12/23 and tumour necrosis factor‐like cytokine 1A ...
Srividya Neelakantan, Christopher Banfield, Kenneth Hung, Anna Sapone, Vivek Pradhan, Yuxi Zhao, Dana Parsons‐Rich, Grace Lee, Bryce G. Johnson, Elena Peeva, Michael S. Vincent, Valerie M. Clerin   +11 more
wiley   +1 more source

Combination adjuvants drive long-lived plastic Th17 cells that convert to multi-functional Th1 cells and protect mice against fungal infection. [PDF]

mBio
Wüthrich M, Okaa UJ, Ledesma Taira C, Dos Santos Dias L, Klein BS.   +4 more
europepmc   +1 more source