Results 131 to 140 of about 4,870,412 (256)

Inflammatory Signatures Beyond Th1/Th2 Endotypes Provide Insights Into Postoperative Recurrence in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) represents a spectrum of inflammatory endotypes, driven by distinct T helper (Th) immune responses. The high rate of recurrent disease despite appropriate medical and surgical interventions highlights the need for improved characterization beyond the traditional type 2 and non‐type 2 phenotypes to better
Liyona Kampel, Narin N. Carmel, Shaun Edalati, Hen Chaushu, Forsan Jahshan, Yaniv Hadi, Timur Pestrikov, Leonor Leider Trejo, Nidal Muhanna, Avraham Abergel   +9 more
wiley   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

The mechanism of how miR-155 regulates Treg/Th17 cells differentiation and Th17 cell function.

, 2013
A. Signaling pathways that are involved in regulating Treg and Th17 cells differentiation and function. IL-2 and TGF-β1 induce the differentiation of Treg cells by enhancing the expression of phospho (p)-STAT5 and p-SMAD5, respectively.
Yu-Lan Ma (302641), Rui Yao (205074), Yu-Hua Liao (168020), Zhi-Jun Ma (302648), Xian Yu (302651), Wei Liang (26352), Huan-Huan Li (302645)   +6 more
core   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

The correlation between the percentages of Th17, Th22 and Th17/Th22 cells in patients.

, 2013
The potential correlations among different subsets of CD4+ T cells were analyzed by Spearman rank correlation test. Data shown are the mean values of individual patients (n = 27).
Di Peng (432822), Ye Wang (41998), Hui Guo (110581), Bingchuan Xu (432823), Yanfang Jiang (162530)   +4 more
core   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

Mast Cells Promote Inflammatory Th17 Cells and Impair Treg Cells Through an IL-1β and PGE2 Axis

Edouard Leveque,1,2 Régis Joulia,3 Louise Battut,2,4 Camille Laurent,1,2,5 Salvatore Valitutti,1,2,5 Nicolas Cénac,2,4 Gilles Dietrich,2,4 Eric Espinosa2,4 1Centre de Recherche en Cancérologie de Toulouse (CRCT), INSERM UMR1037, CNRS UMR5071, Toulouse, F-
Leveque E, Joulia R, Valitutti S, Espinosa E, Laurent C, Dietrich G, Cénac N, Battut L   +7 more
core  

Long term follow-up of platelet count, Treg cells percentage, Th17 cells percentage and Treg/Th17 ratio.

, 2013
A. Platelet count of CR patients at diagnosis, 1month after the initial of treatment, 2 months and 12 months after diagnosis. B. Platelet count of NR patients at diagnosis, 1month after the initial of treatment, 2 months and 12 months after diagnosis. C.
Feng Li (30515), Shanhua Zou (296028), Weiguang Wang (296029), Hao Chen (5190), Yanxia Zhan (296026), Fanli Hua (296027), Lili Ji (296025), Zhihui Min (296030), Dongli Song (293532), Yunfeng Cheng (296031)   +9 more
core   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source