Results 171 to 180 of about 4,547,937 (252)

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Th17 cells require the DNA repair sensor xeroderma pigmentosum complementation Group C to control oxidative DNA damage in a murine model. [PDF]

Nat Commun
Leite JA, Bos NN, Menezes-Silva L, Martins da Silva E, Silva Leandro GD, Moreira de Goes GC, da Silva P, Oliveira S, de Almeida Santos ES, Ranfley H, Palagi I, Andrade-Silva M, Ferreira CP, Nery Neto JAO, Yuji Yariwake V, Cipelli M, Leocata B, Gonçalves T, Gabry da Silveira A, Baroni S, Weiner HL, Hofmann TG, Scheu S, Neves BJ, de Souza-Pinto NC, Colli LM, Waisman A, Marcia Muxel S, Menck CFM, Câmara NOS.   +29 more
europepmc   +1 more source

Probiotic Spore Inspired Oral Drug Delivery System With Multiple‐Barriers‐Crossing Ability Modulates Gut‐Brain Axis for Parkinson's Disease Therapy

Exploration, EarlyView.
Inspired by the germination of probiotic spores, we utilize the excellent characteristics of spores to break through multiple barriers of oral brain‐targeted delivery. Besides the probiotics mediated gut‐brain communication, the spore coat proteins derived nanosystems with multiple‐barriers‐crossing ability alleviate neurodegeneration.
Qianhua Feng, Yuying Mei, Jia Zhang, Liying Sun, Bingqian Si, Huimin Zhou, Huifang Xiao, Runhan Liu, Jieyun Zhang, Lei Wang   +9 more
wiley   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Cryptotanshinone alleviates DSS-induced colitis in mouse by regulating the balance of Treg/Th17 cells and M1 macrophage activation. [PDF]

Eur J Histochem
Liu L, Huang W, Wu Y, Ye G, Zhang J, Shen T, Ouyang C.   +6 more
europepmc   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Epithelial pyroptosis-induced TREM1⁺ macrophages activate Th17 cells to accelerate oral mucosal inflammation. [PDF]

Cell Death Discov
Shang Q, Wang Z, Peng J, Yang D, Li W, Huang X, Qing M, Cheng H, Liu J, Dan H, Zeng X, Zhou Y, Zhang D, Xu H, Chen Q.   +14 more
europepmc   +1 more source

Distinct effects of different Bacteroides strains on depressive-like behavior via a gut-Th1/Th17 cells-brain axis. [PDF]

Commun Biol
Li Z, Qin P, Sun Z, Li L, Liang P, Zhao Y, Ren S, Wang G, Yang J.   +8 more
europepmc   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

Fructose intake driven glycolysis-ROS-EGFR axis specifically promotes the generation and pathogenicity of Th17 cells. [PDF]

Nat Commun
Liu X, Hu W, Sun J, Wu B.
europepmc   +1 more source