Results 171 to 180 of about 4,870,412 (256)

Mast cell-derived MIF Polarizes Th17 cells to drive lung adenocarcinoma progression. [PDF]

Cancer Immunol Immunother
Peng Q, Ye X, Xu X, Song J, Yang Z, Xiao H.   +5 more
europepmc   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

Itaconate and its derivatives ameliorate autoimmunity by suppressing Th17 cells via regulating mitophagy. [PDF]

Cell Commun Signal
Li F, Huang Q, Zheng N, Zhang W, Luo S, Wang R, Bathini T, Sun P, Li X, Huang X, Maj T.   +10 more
europepmc   +1 more source

Shared Genetic Pathways Linking Oral Diseases to Gastrointestinal Disorders: An Integrative Multi‐Omics Study

iMetaMed, EarlyView.
Shared genetics pathways connect oral diseases and gut disorders. ABSTRACT Oral diseases are highly prevalent and increasingly recognized as contributors to gastrointestinal disorders. Despite clinical observations of oral–gut comorbidity, the underlying genetic architecture and causal mechanisms remain poorly understood.
Rui Zhang, Yuelan Gao, Yuyang Zhao, Wanyang Zhong, Xingxiang Duan, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Th17 cells favor migration and invasiveness of cervical cancer cells under hypoxia in an IGF2BP2-dependent manner. [PDF]

Int J Cancer
Gies S, Pohlers M, Tänzer T, Ampofo E, Laschke MW, Schäfer M, Kim YJ, Bohle RM, Solomayer EF, Wagner K, Empting M, Kiemer AK, Walch-Rückheim B.   +12 more
europepmc   +1 more source

Chronic High‐Salt Intake Reprograms Metabolic Homeostasis Driven by Dietary Rice Varieties via Microbial and Metabolite Associations

iMetaMed, EarlyView.
Using a 2% salt diet and a 10‐month feeding to model chronic human sodium exposure, we found that black rice improved glucose tolerance and short‐chain fatty acids, but 2% salt inverted black rice's blood glucose benefits. White rice + 2% salt treatment uniquely increased short‐chain fatty acids.
Xiaofang Li, Fangyang Chen, Ping Chen, Yage Wang, Mengke Yuan, Zhuojun Li, Hao Chen, Zongkang Zhang, Kaikai Li   +8 more
wiley   +1 more source

A thermosensitive hydrogel encapsulating 2-DG alleviates periodontitis by inhibiting glycolysis and effector response of Th17 cells. [PDF]

Front Pharmacol
Zhao R, Li J, Yin J, Xu J, Chen C, Yan J, Chen S, Fu J, Wu J.   +8 more
europepmc   +1 more source

Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Research Progress and Precision Diagnosis‐Therapy Under the Integrated Neuro–Immune–Metabolic–Microbiota Axis Framework

iMetaMed, EarlyView.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is increasingly recognized as a systemic disorder rather than a purely local prostate disease. The diagram illustrates the transition from the traditional local prostate‐centered model to a multi‐axis systemic framework involving clinical heterogeneity, local prostatic inflammation, systemic ...
Kun Wang, Jinfei Liu, Qiangsheng Wang, Lei Fan, Ziang Li, Xuexin Yu, Yonghao Chen, Xiaofan Lu, Guiyi Liao, Jialin Meng, Yu Guan   +10 more
wiley   +1 more source

Combination adjuvants drive long-lived plastic Th17 cells that convert to multi-functional Th1 cells and protect mice against fungal infection. [PDF]

mBio
Wüthrich M, Okaa UJ, Ledesma Taira C, Dos Santos Dias L, Klein BS.   +4 more
europepmc   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source