A proposed mechanistic framework of systemic lupus erythematosus (SLE) and autoimmune thyroid disease (AITD) pathogenesis. In Stage 1, genetically susceptible individuals harbor risk variants within major histocompatibility complex (HLA) and non‐HLA loci that impair central and peripheral immune tolerance mechanisms within the thymic and peripheral ...
Elisa Elisa +3 more
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Increased circulating Th17 cells and altered CD4 T cell maturation and differentiation in active tuberculosis with type 2 diabetes: a pilot study. [PDF]
Ogongo P +13 more
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Fungal pathogen-responsive Th17 cells in gut-mouth axis enhance protection against oropharyngeal candidiasis. [PDF]
Kaji E +9 more
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ATP/P2X7 receptor signal aggravates ischemic stroke injury by activating Th17 cells via STAT3/IL-21 pathway. [PDF]
Liu W +8 more
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Th9 and Th17 Cells in Human Ulcerative Colitis-Associated Dysplastic Lesions. [PDF]
Cui G, Yuan A, Sørbye SW, Florholmen J.
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GPR55 Antagonist CID16020046 Suppresses Collagen-Induced Rheumatoid Arthritis by Suppressing Th1/Th17 Cells in Mice. [PDF]
Lee JE, Im DS.
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Endoscopic healing in pediatric IBD perpetuates a persistent signature defined by Th17 cells with molecular and microbial drivers of disease. [PDF]
Siebert K +18 more
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•Th17 cells are increased in the blood of depressed patients.•Th17 cells promote depressive-like behaviors in mice.•Th17 cells are pathogenic in most CNS diseases.•Th17 cells accumulate in the brain of mice exhibiting depressive-like behavior.
Jeffrey A Lowell, Eléonore Beurel
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