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International Immunopharmacology, 2011
Naïve T cells are multipotential precursors that differentiate into various effector subsets, such as T helper type 1 (Th1) and Th2 cells, which are characterized by their distinct functions. The IL-17-producing T helper (Th17) cell has been recently identified as a new subset of the T helper cell and a mediator of inflammation associated with various ...
Akihiro, Kimura, Tadamitsu, Kishimoto
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Naïve T cells are multipotential precursors that differentiate into various effector subsets, such as T helper type 1 (Th1) and Th2 cells, which are characterized by their distinct functions. The IL-17-producing T helper (Th17) cell has been recently identified as a new subset of the T helper cell and a mediator of inflammation associated with various ...
Akihiro, Kimura, Tadamitsu, Kishimoto
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Th17 cells in inflammation and autoimmunity
Autoimmunity Reviews, 2014T helper 17 (Th17), a distinct subset of CD4(+) T cells with IL-17 as their major cytokine, orchestrate the pathogenesis of inflammatory and autoimmune diseases. Dysregulated Th17 cells contribute to inflammatory and autoimmune diseases. Candidate biologics are in development for targeting IL-17, IL-17 receptors or IL-17 pathways.
David Wong +2 more
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Current Molecular Medicine, 2008
Chronic inflammation is a key feature of many airway diseases. Leukocyte accumulation in the lung has the capacity to mediate many aspects of the pathophysiology of such diseases including asthma and chronic obstructive pulmonary disease (COPD). Until recently, the CD4+ lymphocyte component of these inflammatory influxes was thought to consist of Th1 ...
Suzanne L, Traves, Louise E, Donnelly
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Chronic inflammation is a key feature of many airway diseases. Leukocyte accumulation in the lung has the capacity to mediate many aspects of the pathophysiology of such diseases including asthma and chronic obstructive pulmonary disease (COPD). Until recently, the CD4+ lymphocyte component of these inflammatory influxes was thought to consist of Th1 ...
Suzanne L, Traves, Louise E, Donnelly
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The role of Th17 cells in psoriasis
Immunologic Research, 2020T helper 17 (Th17) cells have been involved in the pathogenesis of many autoimmune and inflammatory diseases, like psoriasis, multiple sclerosis (MS), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD). However, the role of Th17 cells in psoriasis has not been clarified completely.
Binbin Li +10 more
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Annual Review of Immunology, 2009
CD4+T cells, upon activation and expansion, develop into different T helper cell subsets with different cytokine profiles and distinct effector functions. Until recently, T cells were divided into Th1 or Th2 cells, depending on the cytokines they produce.
Thomas, Korn +3 more
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CD4+T cells, upon activation and expansion, develop into different T helper cell subsets with different cytokine profiles and distinct effector functions. Until recently, T cells were divided into Th1 or Th2 cells, depending on the cytokines they produce.
Thomas, Korn +3 more
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Contextualizing TH17 cells in cancer
Nature Reviews ImmunologyThe immune system has evolved intricate and sophisticated mechanisms to recognize and eliminate tumours. Among these, T helper 17 (TH17) cells seem to have a complex role in tumour immunity. Substantial evidence indicates that TH17 cells can impair the ability of immune cells to kill tumours, but growing research suggests that TH17 cells may also be ...
Declan Pang +3 more
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Th17 cells in autoimmune diseases
Frontiers of Medicine, 2015Th17 cells are a new subset of CD4(+) T cells involved in the clearance of extracellular pathogens and fungi. Accumulating evidence suggests that Th17 cells and their signature cytokines have a pivotal role in the pathogenesis of multiple autoimmune-mediated inflammatory diseases.
Lei, Han +5 more
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Th17 Cells in Cardiovascular Disease
Cell Biochemistry and FunctionABSTRACT Recent research has shown a strong link between Th17 cells and their cytokine IL‐17, and various cardiovascular diseases such as atherosclerosis, myocardial infarction, myocarditis, and arrhythmia. Moreover, Th17 cell signalling is likely to be a key factor in cardiovascular disease.
Ke Yang +7 more
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Changes of Th17/Tc17 and Th17/Treg cells in endometrial carcinoma
Gynecologic Oncology, 2014T helper 17 (Th17), T cytotoxic 17 (Tc17) and regulatory T (Treg) cells are important factors in the pathogenesis of inflammatory and autoimmune diseases. However, information concerning the roles of these cells in antitumor immunity or endometrial tumorigenesis remains limited.
Wenjing, Zhang +7 more
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TH17 cells thirsty for calcium
Nature Reviews Immunology, 2019Stefan Feske and colleagues show that calcium signalling in TH17 cells promotes a pathogenic phenotype by regulating mitochondrial function and the antioxidant response.
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