Results 211 to 220 of about 12,148,459 (347)

Establishment of pediatric reference ranges for circulating naïve and memory T and B cell subsets guided by the human immunophenotyping consortium standardization initiative: A large, single center U.S. experience

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Cigarette smoke exposure promotes differentiation of CD4+T cells toward Th17 cells by CD40-CD40L costimulatory pathway in mice

, 2018
Yi Liang,1 Ying Shen,2 Liangjian Kuang,1 Guang Zhou,1 Longju Zhang,1 Xiaoning Zhong,1 Jianquan Zhang,1 Jifeng Liu1 1Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, 2Division of General Practice, General ...
Liu J, Zhang J, Liang Y, Kuang L, Zhou G, Zhong X, Zhang L, Shen Y   +7 more
core  

BCL6 promotes CCR2-driven CNS infiltration of encephalitogenic Th17 cells. [PDF]

J Neuroimmunol
Kumar G, Allushi B, Quinn JL, Maria Z, Testut M, Massey K, Ko R, Axtell RC.   +7 more
europepmc   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Smart Nanodelivery Systems for Immunometabolic Modulation in Osteoarthritis

Exploration, EarlyView.
Smart nanodelivery systems deliver therapeutic payloads across the cartilage matrix to ensure their sustained accumulation within chondrocytes at sites of injury. By targeting specific molecular targets and signaling pathways, these platforms modulate the pathological synovium‐cartilage axis to restore immunometabolic homeostasis and drive tissue ...
Qirui Zhao, Zhewen Mi, Shuya Liu, Shijun Liang, Linjia Peng, Zixuan Gao, Jiaming Li, Xiaoqing Lu, Zhiguang Ren, Yongjie Wan, Shengsheng Cui, Longlong Lu, Xiaoyang Gao, Tao Wang, Hui Liang, Furong Tian, de la Fuente Jesus M, Chong Xiang, Luyi Sun, Lichen Xiang, Daxiang Cui   +20 more
wiley   +1 more source

Pro-inflammatory intestinal Th17-cells are tissue-resident, accumulate in the epithelia in Crohn's disease, and predict unresponsiveness to vedolizumab. [PDF]

J Crohns Colitis
Paroni M, Faggiano C, Righetti C, Dusetti I, Ranzani V, Moschetti G, Noviello D, Vasco C, Vecchi M, Landini P, Facciotti F, Abrignani S, Caprioli F, Geginat J.   +13 more
europepmc   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Metabolic checkpoints in the regulation of Th17 cells: implications for uveitis pathogenesis and therapy. [PDF]

Front Immunol
Ma Y, Zhang Q, Ding Z.
europepmc   +1 more source

IL-15 Promotes Inflammatory Th17 Cells in the Intestine. [PDF]

Inflamm Bowel Dis
Hou G, Lee A, Golob JL, Grasberger H, Berinstein E, Swanson BJ, Bishu SR, Zataari ME, Khaykin V, Berinstein JA, Fry C, Nemzek J, Kamada N, Kao J, Bishu S.   +14 more
europepmc   +1 more source