Results 211 to 220 of about 4,870,412 (256)

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

A20's linear ubiquitin-binding motif restrains pathogenic activation of Th17 cells and IL-22-driven enteritis. [PDF]

J Clin Invest
Bowman CJ, Stibor DM, Sun X, Lenci N, Shimizu H, Yamashita EF, Advincula R, Kim MC, Turnbaugh JA, Sun Y, Razani B, Turnbaugh PJ, Ye CJ, Malynn BA, Ma A.   +14 more
europepmc   +1 more source

Habitual Diet, Gut Microbiome Dysbiosis, and α‐Synucleinopathy Conversion in Isolated Rapid Eye Movement (REM) Sleep Behavior Disorder

Movement Disorders, EarlyView.
Abstract Background Accumulating evidence indicates that habitual diet, including plant‐based dietary patterns, is associated with neurodegenerative α‐synucleinopathy risk. However, the role of diet and its correlation with the gut microbiome in prodromal α‐synucleinopathy, specifically among patients with isolated rapid eye movement (REM) sleep ...
Suyi Xie, Yuhua Yang, Shi Tang, Li Zhou, Jing Wang, Joey W.Y. Chan, Brian Or, Ningning Li, Siyi Gong, Zhixuan He, Jianzhang Ni, Yaping Liu, Jihui Zhang, Paul K.S. Chan, Zigui Chen, Sunny Hei Wong, Vincent C.T. Mok, Ngan Yin Chan, Steven W.H. Chau, Yun Kwok Wing, Bei Huang   +20 more
wiley   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

The intrinsic expression of NLRP3 in Th17 cells promotes their protumor activity and conversion into Tregs. [PDF]

Cell Mol Immunol
Accogli T, Hibos C, Milian L, Geindreau M, Richard C, Humblin E, Mary R, Chevrier S, Jacquin E, Bernard A, Chalmin F, Paul C, Ryffel B, Apetoh L, Boidot R, Bruchard M, Ghiringhelli F, Vegran F.   +17 more
europepmc   +1 more source

Pharmacokinetic and Pharmacodynamic Interactions Between Anti‐Asthma Drugs and Medicinal Plants: A Comprehensive Review

Phytotherapy Research, EarlyView.
ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts.
Emine Kocyigit, Aylin Bülbül, Betul Kocaadam‐Bozkurt, Osman Bozkurt, Duygu Ağagündüz, Raffaele Capasso   +5 more
wiley   +1 more source

Periodontitis aggravates pulmonary fibrosis by <i>Porphyromonas gingivalis</i>-promoted infiltration of neutrophils and Th17 cells. [PDF]

Front Cell Infect Microbiol
Ye HL, Meng XQ, Li H, Sun X, Lin WZ, Zhou LJ, Zhang J, Hou C, Xu S, Chen BY, Qiu C, Li YL, Wang YL, Yan LF, Duan SZ.   +14 more
europepmc   +1 more source

Multi‐Target Pharmacological Mechanisms of Salvia miltiorrhiza Bunge in Metabolic Syndrome and Cardiovascular Diseases: A Comprehensive Review Based on the Theory of “Same Treatment for Different Diseases”

Phytotherapy Research, EarlyView.
Salvia miltiorrhiza Bunge in metabolic syndrome and cardiovascular diseases: multi‐target actions on shared signaling pathways. ABSTRACT Metabolic syndrome (MetS) represents a clinical disorder characterized by the clustering of conditions including obesity, elevated blood sugar levels, and high lipid levels, which are intricately linked to the onset ...
Zhiyi Jia, Kaiyi Wu, Jiaying Qi, Nana Huang, Yusheng Liu, Xiumei Gao, Rong Sun   +6 more
wiley   +1 more source

Sp3 ameliorated experimental autoimmune encephalomyelitis by triggering Socs3 in Th17 cells. [PDF]

J Adv Res
Li Y, Zhu M, Yang P, Chen D, Zhou D, Ren Y, Zhang Z, Ruan C, Da Y, Zhang R.   +9 more
europepmc   +1 more source

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source