Results 211 to 220 of about 127,043 (265)

Age‐related clinical heterogeneity and peripheral T cell profile alterations in primary Sjögren's disease: A retrospective study of 5778 patients

Rheumatology &Autoimmunity, EarlyView.
This large‐scale retrospective study of 5778 primary Sjögren's disease (SjD) patients, stratified by diagnostic age, defines a distinct clinical and immunological profile for early‐diagnosed (<45 years) disease. We identified early diagnosis as an independent risk factor for hypergammaglobulinemia and interstitial lung disease, underpinned by a ...
Yuan Ning, Ruiling Feng, Kai Zhang, Yipeng Han, Ruoyi Wang, Guangwen Li, Yuebo Jin, Jing He   +7 more
wiley   +1 more source

Gut microbiota-driven pathogenic Th17 cells mediated autoimmune epididymo-orchitis in a mouse model of colitis. [PDF]

iScience
Zeng Q, Liu JC, Yang C, Lyu M, Li D, Yeung WSB, Chiu PCN, Zhang T, Duan YG.   +8 more
europepmc   +1 more source

Baseline Neutrophil‐To‐Lymphocyte Ratio as a Risk Stratification Marker for Severe Checkpoint Inhibitor Pneumonitis in Patients With Non‐Small Cell Lung Cancer: A Two‐Cohort Study With Retrospective Discovery and Prospective Validation

Respirology, EarlyView.
The association between baseline neutrophil‐to‐lymphocyte ratio (NLR) and severe checkpoint inhibitor pneumonitis (CIP) was analyzed in discovery retrospective and validation prospective cohorts. Higher baseline NLR (≥ 4.75) was associated with increased severe CIP incidence in both cohorts.
Tetsu Hirakawa, Kakuhiro Yamaguchi, Shun Takao, Nobuhiro Kanaji, Naoko Matsumoto, Kozue Miyazaki, Tamio Okimoto, Chihiro Ando, Hisao Higo, Masaaki Yanai, Koji Kurose, Yasunari Nagasaki, Masako Watanabe, Kosuke Oyama, Yuko Toyoda, Yoshihiro Taguchi, Shimpei Tada, Kiyofumi Shimoji, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Taku Nakashima, Hiroshi Iwamoto, Hironobu Hamada, Noboru Hattori   +24 more
wiley   +1 more source

CRIF1 gene therapy ameliorates inflammatory bowel disease by suppressing TH17 cells and fibrosis through mitochondrial function regulation. [PDF]

Front Immunol
Park JS, Kang HY, Jeong HY, Yang S, Choi J, Cho SH, Kim S, Lee BI, Cho ML.   +8 more
europepmc   +1 more source

Protocol for CRISPR-mediated deletion of cis-regulatory element in murine Th17 cells for in vivo assessment of effector function. [PDF]

STAR Protoc
Zhong X, Wu H, Wang G, Sun Z.
europepmc   +1 more source

Unfolding the Role of Th17 Cells in Neutrophilic Lung Inflammation. [PDF]

Am J Respir Cell Mol Biol
Remcho TP, Kolls JK.
europepmc   +1 more source

Inflammation-Induced Th17 Cells Synergize with the Inflammation-Trained Microbiota to Mediate Host Resiliency Against Intestinal Injury. [PDF]

Inflamm Bowel Dis
Golob JL, Hou G, Swanson BJ, Berinstein JA, Bishu S, Grasberger H, Zataari ME, Lee A, Kao JY, Kamada N, Bishu S.   +10 more
europepmc   +1 more source

Effect of QingreHuoxue formula on Th17 cells and Tregs in mice with idiopathic membranous nephropathy. [PDF]

Am J Transl Res
Lou C, Zhou Y, Liao J, Xu X, Huang K, Fan X, Hu P, Wang X, Feng B, Zhu F.   +9 more
europepmc   +1 more source

Crosstalk with infant-derived Th17 cells, as well as exposure to IL-22 promotes maturation of intestinal epithelial cells in an enteroid model. [PDF]

Front Immunol
Sharafian Z, Littlejohn PT, Michalski C, Sousa JA, Cheung J, Hill M, Piper H, Jacobson K, Lavoie PM, Allaire JM, Vallance BA.   +10 more
europepmc   +1 more source

Th17 cells in depression

Brain, Behavior, and Immunity, 2018
T helper 17 (Th17) cells have recently been implicated in depression, which adds to the list of several other diseases of the central nervous system (CNS) that are already known to involve Th17 cells. In CNS diseases, it is thought that the signature cytokine produced by Th17 cells, interleukin-17A (IL-17A), mediates the detrimental effects of Th17 ...
Jeffrey A Lowell, Eleonore Beurel
exaly   +4 more sources