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Changes of Th17/Tc17 and Th17/Treg cells in endometrial carcinoma
Gynecologic Oncology, 2014T helper 17 (Th17), T cytotoxic 17 (Tc17) and regulatory T (Treg) cells are important factors in the pathogenesis of inflammatory and autoimmune diseases. However, information concerning the roles of these cells in antitumor immunity or endometrial tumorigenesis remains limited.
Wenjing, Zhang +7 more
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Th17 cells in renal inflammation and autoimmunity.
Autoimmunity Reviews, 2019Th17 cells are a distinct lineage of T-cells. These T-cells express IL-17A and the lineage-defining transcription factor RORγt. Th17 cells have a pivotal, physiological role in host defense against pathogens.
S. Dolff, O. Witzke, B. Wilde
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TH17 cells thirsty for calcium
Nature Reviews Immunology, 2019Stefan Feske and colleagues show that calcium signalling in TH17 cells promotes a pathogenic phenotype by regulating mitochondrial function and the antioxidant response.
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The involvement of TH17 cells in the pathogenesis of IBD.
Cytokine & growth factor reviews, 2022Ping Jiang +6 more
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Blood, 2009
In this issue of Blood , Kryczek and colleagues show that a potent proinflammatory T-cell subset, IL-17–producing Th17 cells, can be found in ovarian cancers, and that their presence correlates with significantly enhanced survival.
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In this issue of Blood , Kryczek and colleagues show that a potent proinflammatory T-cell subset, IL-17–producing Th17 cells, can be found in ovarian cancers, and that their presence correlates with significantly enhanced survival.
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TH17 Cells in Fungal Infections
2011Although TH1 responses driven by the IL-12/IFN-gamma axis are central to protection against fungi, the paradigm has been revisited with two new T cell populations entering the scene: the TH17 cells involved in inflammatory responses, and the T regulatory cells (Tregs), which minimize immune responses to avoid damage to the host. While many studies have
ZELANTE, TERESA +2 more
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Migration and Function of Th17 Cells
Inflammation & Allergy - Drug Targets, 2009T cells play central roles in regulation of the immune system in mammals. T cell receptor alphabeta T cells that can produce the cytokine IL-17 are called Th17 cells and form a lineage of effector T cells that are distinct from Th1, Th2 and FoxP3(+) T cells.
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Th17 cells in immunity and autoimmunity
Annals of the Rheumatic Diseases, 2008The primary function of Th17 cells appears to be the clearance of extracellular pathogens during infections. However, Th17 cells also promote inflammation and have been implicated in the pathogenesis of many experimental autoimmune diseases and human inflammatory conditions. Transforming growth factor beta (TGFbeta) is a critical differentiation factor
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