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A role for Th1-like Th17 cells in the pathogenesis of inflammatory and autoimmune disorders
Molecular Immunology, 2019HighlightsEvidences for Th17 cells plasticity are reviewed.Highlights the importance of Th17 cells plasticity in immune diseases.Th1‐like Th17 cells play pivotal role in autoimmune disorders. Abstract The T helper 17 (Th17) cells contain a dynamic subset
Ali N Kamali +2 more
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The pathogenicity of Th17 cells in autoimmune diseases
Seminars in Immunopathology, 2019Keiko Yasuda +2 more
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T helper 17 (Th17) cells and interleukin-17 (IL-17) in cancer
Archives of Pharmacal Research, 2019Seon Hee Chang, Chang Seon Hee
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International Immunopharmacology, 2011
Naïve T cells are multipotential precursors that differentiate into various effector subsets, such as T helper type 1 (Th1) and Th2 cells, which are characterized by their distinct functions. The IL-17-producing T helper (Th17) cell has been recently identified as a new subset of the T helper cell and a mediator of inflammation associated with various ...
Akihiro, Kimura, Tadamitsu, Kishimoto
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Naïve T cells are multipotential precursors that differentiate into various effector subsets, such as T helper type 1 (Th1) and Th2 cells, which are characterized by their distinct functions. The IL-17-producing T helper (Th17) cell has been recently identified as a new subset of the T helper cell and a mediator of inflammation associated with various ...
Akihiro, Kimura, Tadamitsu, Kishimoto
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The Role of TH17 Cells in Multiple Sclerosis: Therapeutic Implications.
Autoimmunity Reviews, 2020Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) where immunopathology is thought to be mediated by myelin-reactive CD4+ T helper (TH) cells. The TH cells most commonly implicated in the pathogenesis of
T. Moser +4 more
semanticscholar +1 more source
Current Molecular Medicine, 2008
Chronic inflammation is a key feature of many airway diseases. Leukocyte accumulation in the lung has the capacity to mediate many aspects of the pathophysiology of such diseases including asthma and chronic obstructive pulmonary disease (COPD). Until recently, the CD4+ lymphocyte component of these inflammatory influxes was thought to consist of Th1 ...
Suzanne L, Traves, Louise E, Donnelly
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Chronic inflammation is a key feature of many airway diseases. Leukocyte accumulation in the lung has the capacity to mediate many aspects of the pathophysiology of such diseases including asthma and chronic obstructive pulmonary disease (COPD). Until recently, the CD4+ lymphocyte component of these inflammatory influxes was thought to consist of Th1 ...
Suzanne L, Traves, Louise E, Donnelly
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Human Immunology, 2020
Th17 cells, known as a highly pro-inflammatory subtype of Th cells, are involved very early in numerous aspects of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) neuropathology.
R. Bălaşa +5 more
semanticscholar +1 more source
Th17 cells, known as a highly pro-inflammatory subtype of Th cells, are involved very early in numerous aspects of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) neuropathology.
R. Bălaşa +5 more
semanticscholar +1 more source
Th17 cells in autoimmune diseases
Frontiers of Medicine, 2015Th17 cells are a new subset of CD4(+) T cells involved in the clearance of extracellular pathogens and fungi. Accumulating evidence suggests that Th17 cells and their signature cytokines have a pivotal role in the pathogenesis of multiple autoimmune-mediated inflammatory diseases.
Lei, Han +5 more
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Contextualizing TH17 cells in cancer
Nature Reviews ImmunologyThe immune system has evolved intricate and sophisticated mechanisms to recognize and eliminate tumours. Among these, T helper 17 (TH17) cells seem to have a complex role in tumour immunity. Substantial evidence indicates that TH17 cells can impair the ability of immune cells to kill tumours, but growing research suggests that TH17 cells may also be ...
Declan Pang +3 more
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Th17 Cells in Cardiovascular Disease
Cell Biochemistry and FunctionABSTRACT Recent research has shown a strong link between Th17 cells and their cytokine IL‐17, and various cardiovascular diseases such as atherosclerosis, myocardial infarction, myocarditis, and arrhythmia. Moreover, Th17 cell signalling is likely to be a key factor in cardiovascular disease.
Ke Yang +7 more
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