Results 271 to 280 of about 709,386 (365)

The universal role of adaptive transcription in health and disease

The FEBS Journal, EarlyView.
Adaptive transcription via molecules such as CREB, MEF2, SRF, AP1, Nr4a1, and Egr1 constitutes a universal mechanism for directed cell state transitions in health and disease. These molecules are involved in physiological adaptation processes, pathological maladaptations, curative adaptations, and development of resistance to treatment.
Thomas Lissek
wiley   +1 more source

Therapeutic effect of miR-30b-5p-loaded lentivirus on experimental autoimmune uveitis via inhibiting Notch signaling activation. [PDF]

J Transl Med
Yin X, Wei H, Guo L, Liu B, Peng Y, Zhou M, Qiu Y, Qu R, Gao Y, Wu Q, Jiang W, Bi H, Guo D.   +12 more
europepmc   +1 more source

Are single nucleotide polymorphisms underutilized for guiding treatment of inflammatory bowel disease?

Immunology &Cell Biology, EarlyView.
Patients with inflammatory bowel disease (IBD) show variation in their response to therapeutics. This review explores the contrast between heritable single nucleotide polymorphisms (SNPs) that contribute the pathogenesis of IBD, versus those that associate with response to treatments.
Jildou van der Werf, Nicholas Ian Fleming   +1 more
wiley   +1 more source

T helper 17 cells and interleukin-17 immunity in type 1 diabetes: From pathophysiology to targeted immunotherapies. [PDF]

World J Diabetes
Vasilev G, Kokudeva M, Siliogka E, Padilla N, Shumnalieva R, Della-Morte D, Ricordi C, Mihova A, Infante M, Velikova T.   +9 more
europepmc   +1 more source

The effects of GLP‐1RA on inflammatory skin diseases: A comprehensive review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
The graphical abstract illustrates the aim of this article, which was to comprehensively review the literature and to collect, analyse and quantitatively resynthesize evidence on the possible effects of GLP‐1RA on inflammatory skin diseases. The actions of GLP‐1RA on glucose regulation, weight management and cardiovascular risk are listed, while the ...
Ioanna A. Paschou, Evangelia Sali, Stavroula A. Paschou, Theodora Psaltopoulou, Electra Nicolaidou, Alexander J. Stratigos   +5 more
wiley   +1 more source

Hippo Signaling Regulates High-NaCl-Induced Increase in RORγt+ Pro-Inflammatory Lymphocytes. [PDF]

Int J Mol Sci
Zeeb BL, Weber-Stiehl S, Escudero-Hernández C, Müller DN, Maifeld A, Sommer F, Schmitt R, Sievers LK.   +7 more
europepmc   +1 more source

Immunopathological Dysregulation in Acute Myeloid Leukemia: The Impact of T-bet, RORγt, and FOXP3 on Disease Dynamics. [PDF]

Cells
Mohy El-Din AMM, AlShaarawy BA, Kandeel EZ, AlDewi DM, Refaat LAA, Arneth B, Sabit H.   +6 more
europepmc   +1 more source

The Mixed Lymphocyte Reaction and the Ratio of CD4+CD25+Foxp3+/Th17 T Cell in Long Term Graft and Recipents Survival of Kidney Transplantation with Living-Related Donor

, 2012
Peng Tian, Z.-K. Jin, Wujun Xue, Jin Zheng, Chenguang Ding, G.-Q. Ge, T.-C. Mao, Wanli Duan, Min Xi   +8 more
openalex   +1 more source

Role of epicardial adipose tissue in heart failure with preserved ejection fraction: An emerging molecular mechanism and therapeutic potential

Obesity Reviews, EarlyView.
Summary With the evolving landscape of diseases, heart failure with preserved ejection fraction (HFpEF) now encompasses more than half of all heart failure patients. This condition is clinically diverse, involving multiple organ systems and often occurring alongside the aging process.
Zhongwen Qi, Dan Wu, Zhipeng Yan, Qing Wang, Yiming Li, Junnan Zhao, Fengqin Xu   +6 more
wiley   +1 more source

Differential Effects of IL4I1 Protein on Lymphocytes From Healthy and Multiple Sclerosis Patients. [PDF]

Pharmacol Res Perspect
Davis SE, Hu J, Nanescu SE, Kumar MN, Baydyuk M, Oft HC, Amjad FS, Wellstein A, Huang JK.   +8 more
europepmc   +1 more source