Results 151 to 160 of about 223,069 (306)

Distribution of participants and of Th1/Th2 cytokine secretion.

, 2013
The distribution of all participants and of the participants with detectable Th1/Th2 cytokine secretion within the three vaccination groups is shown. There was no Th2 cytokine secretion detectable in participants with exclusive wcP preimmunization.
Simon Urschel (354841), Nikolaus Rieber (205867), Bernd H. Belohradsky (354842), Dominik Hartl (205884), Johannes Liese (344753), Anna Graf (354840)   +5 more
core   +1 more source

The synergistic impact of granulocytic myeloid‐derived suppressor cells and innate lymphoid cells in systemic sclerosis

Arthritis &Rheumatology, Accepted Article.
Objective Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized by immune dysregulation and fibrosis, with myeloid‐derived suppressor cells (MDSCs) emerging as important regulators of immune responses. However, the role of MDSCs in SSc‐associated fibrosis and their interactions with other immune cell populations remain poorly ...
Stefanie Weber, Mario R. Angeli, Hashem Mohammadian, Hannah Labinsky, Maria Gabriella Raimondo, Richard Demmler, Yuko Ariza, Thomas Wohlfahrt, Markus Luber, Yi‐Nan Li, Jörg H.W. Distler, Tobias Bäuerle, Georg Schett, Simon Rauber, Andreas Ramming, Alina M. Ramming   +15 more
wiley   +1 more source

Sema4A neutralization reduces fibrosis and inflammation in a mouse model of systemic sclerosis and a 3D model of immunity‐driven fibrosis

Arthritis &Rheumatology, Accepted Article.
Objective We previously showed that Semaphorin4A (Sema4A) is elevated in patients with systemic sclerosis (SSc) and promotes inflammation and fibrosis in vitro. Here, we examined the effect of Sema4A neutralization in vivo and in 3D fibrosis models. Methods Sema4A plasma levels were measured by ELISA in healthy controls (n=31) and patients with SSc (n=
Jaime Marty, Sara Martinez‐Ramos, Carlos Rafael‐Vidal, Beatriz Malvar‐Fernández, Tiago Carvalheiro, Ralph G. Tieland, Ines Ramos, Wiola Marut, Ana Pinheiro‐Lopes, Ana Argibay, Brenda Maure, Caritina Vázquez‐Triñanes, Nair Pérez Gómez, David Fernández‐Fernández, Sandra Vila, Coral Mouriño, Rogier M Thurlings, Arjan van Caam, Alberto Rivera, José María Pego‐Reigosa, Timothy R. Radstake, Samuel Garcia   +21 more
wiley   +1 more source

Extrapolation and pharmacokinetic protocol design optimization for ceftriaxone as an exemplar for the development of antibiotics for children

British Journal of Clinical Pharmacology, EarlyView.
Aim Ceftriaxone is a cephalosporin commonly used for the treatment of acute, severe infections; however, there are conflicting data on its disposition properties in children, making it a suitable case study for the evaluation of the appropriateness of extrapolation approaches based on exposure matching principles for paediatric patients and exploring ...
Daniel Valente Neves, Umberto Villani, Salvatore D'Agate, Sean Oosterholt, Ricardo de Carvalho Cavalli, Fabio Carmona, Vera Lucia Lanchote, Oscar Della Pasqua   +7 more
wiley   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Th1/Th2 imbalance in schizophrenia [PDF]

, 2005
Die Schizophrenie ist eine komplexe Erkrankung, bei der neben einer genetischen Komponente äußere Einflussfaktoren eine wichtige Rolle spielen. Epidemiologische Studien weisen auf eine mögliche Rolle von Virusinfektionen als Umwelt-Faktor in der ...
Chiang, Sonnig Sue Whei
core  

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Organizational Policies and Environmental Innovation: The Mediating Role of Environmental Partnerships

Business Strategy and the Environment, EarlyView.
ABSTRACT Although cross‐sector collaborations drive innovation, organizational policies as legitimation signals attracting such collaborations remain unexplored. This study examines the mediating role of environmental partnerships between organizational policies and environmental innovation.
Jose Nicolas Pacheco, Jasna Poček, Andreu Turro, David Urbano   +3 more
wiley   +1 more source

Significance of Th1 and Th2 Cell Densities and Th1/Th2 Cytokine Profiles in Colorectal Cancer

Background: T-cell densities are associated with colorectal cancer outcome, but the significance of specific Th cell subsets is incompletely understood. We aimed to investigate the role of Th1 and Th2 cells and associated cytokine profiles.
Tapiainen, Vilja V., Karjalainen, Henna, Rautio, Tero, Seppälä, Toni T, Kastinen, Meeri, Elomaa, Hanna, Mecklin, Jukka-Pekka, Äijälä, Ville K, Saarnio, Juha, Mäkinen, Markus J, Mäkinen, Markus J., Wirta, Erkki-Ville, Aro, Raila, Ahtiainen, Maarit, Böhm, Jan, Tuomisto, Anne, Väyrynen, Juha P., Rahkola, Oskari, Tapiainen, Vilja V, Seppälä, Toni T., Rintala, Jukka, Meriläinen, Sanna, Häivälä, Reetta, Väyrynen, Juha P, Helminen, Olli, Kehusmaa, Akseli, Pohjanen, Vesa-Matti, Sirniö, Päivi, Ojanperä, Aino, Äijälä, Ville K., Pohjanen, Vesa‐Matti, Wirta, Erkki‐Ville, Mecklin, Jukka‐Pekka   +32 more
core   +1 more source

Internal Carbon Cycles in the Steel Industry: Pathways for CO2 Management and Carbon Capture Utilization

Chemie Ingenieur Technik, EarlyView.
The steel industry accounts for about 7%‐9% of global CO2 emissions. While H2‐based direct reduction is a long‐term route, near‐term solutions are needed for existing plants. Internal carbon cycles reuse steelworks off‐gases and by‐products, enabling circular carbon use and supporting CCU integration.
Florian Haakmann, Nina Kolbe, Julian Suer, Cássia Castro Müller, Nils Jäger   +4 more
wiley   +1 more source