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Bioactive compound ginkgolide B alleviates food allergy by regulating mTOR signaling pathway. [PDF]
Front ImmunolZhou R +5 more
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Th2 Cells in Health and Disease
Annual Review of Immunology, 2017Helper T (Th) cell subsets direct immune responses by producing signature cytokines. Th2 cells produce IL-4, IL-5, and IL-13, which are important in humoral immunity and protection from helminth infection and are central to the pathogenesis of many allergic inflammatory diseases.
Damon Tumes +2 more
exaly +4 more sources
Revisiting the Th1/Th2 Paradigm [PDF]
Scandinavian Journal of Immunology, 1998 The identification of subsets of CD4+ helper cells producing distinct pattern of cytokines has provided a valuable framework for understanding how different effector populations of immune cells can be recruited in vivo during infection. In the view of most investigators, Th1 and Th2 cells produce factors that serve as their own autocrine factors and ...
Muraille, Eric, Leo, Oberdan
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Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice
Inflammation Research, 2021Histamine derived from mast cells and basophils plays important roles in inducing allergic symptoms. Although T cells also produce histamine, the involvement of the histamine produced from T cells has remained enigmatic. We sought to reveal the roles of T helper 2 (Th2) cell-derived histamine in nasal allergic disorders.The histamine production from ...
Naruhito Iwasaki +6 more
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Current Allergy and Asthma Reports, 2007
Several cysteine and serine protease allergens have been cloned from house dust mites, including Der p 1, Der p 3, Der p 6, and Der p 9. A significant body of evidence suggests that these allergens mimic helper T (Th) 2 cell adjuvants. Der p 1 cleaves CD23 from activated B cells and CD25 from T cells. Der p 1 proteolytically degrades tight junctions in
Martin D, Chapman +2 more
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Several cysteine and serine protease allergens have been cloned from house dust mites, including Der p 1, Der p 3, Der p 6, and Der p 9. A significant body of evidence suggests that these allergens mimic helper T (Th) 2 cell adjuvants. Der p 1 cleaves CD23 from activated B cells and CD25 from T cells. Der p 1 proteolytically degrades tight junctions in
Martin D, Chapman +2 more
openaire +2 more sources
Current Opinion in Hematology, 2001
After activation, CD4 helper T (Th) cells differentiate into Th1or Th2 effector subsets. These two types of cells produce distinct profiles of cytokines and regulate different immune responses. This review summarizes recent progress on different features of co-stimulatory regulation and chemokine-mediated homing of Th1 and Th2 cells.
C, Dong, R A, Flavell
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After activation, CD4 helper T (Th) cells differentiate into Th1or Th2 effector subsets. These two types of cells produce distinct profiles of cytokines and regulate different immune responses. This review summarizes recent progress on different features of co-stimulatory regulation and chemokine-mediated homing of Th1 and Th2 cells.
C, Dong, R A, Flavell
openaire +2 more sources
Th2 responses in schistosomiasis
Seminars in Immunopathology, 2012Schistosomiasis is caused by infection with parasitic flatworms of the genus Schistosoma. It is characterized by the development of strong CD4(+) T cell and B cell responses that, during primary infection, fail to eliminate the parasites, but in collaboration with cells of the innate immune system allow survival in the face of ongoing tissue damage ...
Keke, Fairfax +4 more
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TH2 and ‘TH2-like’ cells in allergy and asthma: pharmacological perspectives
Trends in Pharmacological Sciences, 1994Recently, considerable progress has been made in understanding the molecular basis by which cytokines released from CD4+ helper T cells contribute to allergic disease. A subset of CD4+ helper T cells, termed TH2 cells, produce interleukin 4 (IL-4) and IL-5, but not interferon gamma.
G P, Anderson, A J, Coyle
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