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Th22 and related cytokines in inflammatory and autoimmune diseases
Expert Opinion on Therapeutic Targets, 2012Th22 and related cytokines regulate various processes and have been linked to diverse effects. The levels of Th22 and cytokine IL-22 are increased in several disorders and positively related to some autoimmune diseases. Preclinical studies have suggested that the inhibition or stimulation of IL-22 is an attractive approach to reverse the immune ...
Tian, Tian, Shuang, Yu, Daoxin, Ma
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The Biology and Functions of Th22 Cells
2014T helper (Th) cells develop from naïve CD4(+) T cells under lineage-specific culture conditions and are nominated by their lineage-specific cytokines. Th22 cells, new players in adoptive immune responses, are identified by the production of interleukin (IL)-22.
Lei, Jia, Changyou, Wu
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Skin-Homing Th2/Th22 Cells in Papuloerythroderma of Ofuji
Dermatology, 2014Papuloerythroderma of Ofuji (PEO) appears to be a T cell-mediated skin disease; however, the pathogenesis of PEO remains unclear. We report two cases of PEO and examine cytokine production and expression of skin-homing receptors in circulating T cells in the patients.
Yuichi, Teraki, Yumiko, Inoue
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An increased proportion of circulating Th22 and Tc22 cells in psoriasis
Cellular Immunology, 2014Psoriasis is a common dermatosis mediated by T cells. This study investigated the correlation of Th22 cells and Tc22 cells with psoriasis. A total of 30 psoriasis patients and 11 age- and sex-matched healthy controls were recruited for this study. The proportions of circulating Th22 and Tc22 cells, expression of aryl hydrocarbon receptor, and IL-22 ...
Li, Luan +4 more
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Th22 in inflammatory and autoimmune disease: prospects for therapeutic intervention
Molecular and Cellular Biochemistry, 2011T helper cell 22 (Th22) is a new subset of T cells clearly separate from Th17 and other known T cell subsets with distinct gene expression and function. With the CCR6 + CCR4 + CCR10 + phenotype and aryl hydrocarbon receptor as the key transcription factor, Th22 subsets produce cytokines such as IL-22, whose function depends on the activation of signal ...
Ning, Zhang +2 more
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Th9 and Th22 immune response in young patients with type 1 diabetes
Immunologic Research, 2015Th17, Th22 and Th9 are recently discovered effector populations that may contribute to the pathogenesis of autoimmune and inflammatory diseases. The presented study aimed to investigate the link between Th22 and Th9 subsets in type 1 diabetes, as this disease involves different subsets of CD4+ T lymphocytes.
Monika Ryba-Stanisławowska +2 more
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Induction of skin-pathogenic Th22 cells by epicutaneous allergen exposure
Journal of Dermatological Science, 2017Atopic dermatitis (AD) is a common inflammatory skin disease with dysfunction of the skin barrier, an abnormal immune response and frequent allergies to environmental antigens like food antigens. Clinical observations suggest that certain diets can influence the course of AD.Here we compared the phenotype of food allergen-specific T cells activated ...
Ivana, Glocova +7 more
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Decreased circulating Th22 and Th17 cells in patients with aplastic anemia
Clinica Chimica Acta, 2015Aplastic anemia (AA) is an immune-mediated disorder and mainly related to active destruction of hematopoietic cells by effector T lymphocytes. T helper (Th) 22 cells characterized as a novel subset of CD4+ T cells participate in the pathogenesis of autoimmune and hematological diseases.
Ting Lu +6 more
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Elevated Th22 Cells Correlated with Th17 Cells in Patients with Rheumatoid Arthritis
Journal of Clinical Immunology, 2011T-helper (Th) 22 and Th17 cells are implicated in the pathogenesis of autoimmune diseases. The roles of Th22 cells in the pathophysiology of rheumatoid arthritis (RA) remain unsettled.CD4(+)IFNγ(-)IL17(-)IL-22(+) T cells (Th22 cells), CD4(+)IFNγ(-)IL-22(-)IL17(+) T cells (pure Th17 cells), CD4(+)IL17(+) T cells (Th17 cells), and CD4(+)IFNγ(+) T cells ...
Lei, Zhang +12 more
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Intrarenal and Urinary Th9 and Th22 Cytokine Gene Expression in Lupus Nephritis
The Journal of Rheumatology, 2015Objective.We studied the urinary sediment mRNA level of Th9- and Th22-related cytokines in patients with systemic lupus erythematosus (SLE).Methods.We quantified urinary mRNA levels of interleukin (IL) 9, IL-10, IL-22, and their corresponding transcription factors in 73 patients with active lupus nephritis, 13 patients with hypertensive nephrosclerosis
Cathy Choi-Wan, Luk +8 more
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