Results 91 to 100 of about 10,640,595 (395)

Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine.

International Immunology, 1999
Helper T cells are classified into Th1 and Th2 subsets based on their profiles of cytokine production. Th1 cells are involved in cell-mediated immunity, whereas Th2 cells induce humoral responses.
Toshio Imai, M. Nagira, S. Takagi, M. Kakizaki, M. Nishimura, Jian-bin Wang, P. Gray, K. Matsushima, O. Yoshie   +8 more
semanticscholar   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Polyunsaturated fatty acid-derived lipid mediators and T cell function [PDF]

, 2014
Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY) .
Marelli-Berg, F, Mauro, C, Nicolaou, A, Urquhart, P   +3 more
core   +7 more sources

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, Volume 19, Issue 5, Page 1452-1470, May 2025.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene*

Journal of Biological Chemistry, 1997
Interleukin-5 (IL-5), which is produced by CD4+ T helper 2 (Th2) cells, but not by Th1 cells, plays a key role in the development of eosinophilia in asthma.
Dong-hong Zhang, L. Cohn, P. Ray, K. Bottomly, A. Ray   +4 more
semanticscholar   +1 more source

IL-33 signaling regulates innate and adaptive immunity to Cryptococcus neoformans.

, 2013
Susceptibility to progressive infection with the fungus Cryptococcus neoformans is associated with an allergic pattern of lung inflammation, yet the factors that govern this host response are not clearly understood.
Duerr, Claudia U, Flaczyk, Adam, Fritz, Jörg H, Lafferty, Erin I, Qureshi, Salman T, Shourian, Mitra   +5 more
core   +1 more source

Alternative activation of macrophages by filarial nematodes is MyD88-independent [PDF]

, 2012
Alternative macrophage activation is largely defined by IL-4Rα stimulation but the contribution of Toll-like receptor (TLR) signaling to this phenotype is not currently known.
Adachi, Aderem, Akira, Allen, Andrew S. MacDonald, Babu, Chen, Cliffe, Dalton, deSchoolmeester, Eisenbarth, Fujita, Gaddis, Gordon, Helmby, Hise, Hoerauf, Hoerauf, Iwasaki, Jenkins, Judith E. Allen, Kaisho, Kane, Kasmi, Katie J. Mylonas, Kawai, Kim, Koide, Kroeger, Liu, Loke, Loke, Loke, Louis, MacDonald, Marieke A. Hoeve, Meyer, Munder, Muraille, Mylonas, Nair, Nair, Ohnmacht, Perrigoue, Pesce, Phythian-Adams, Piggott, Rao, Schabussova, Schnare, Tawill, Taylor, Turner, van Stijn   +53 more
core   +1 more source

IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells.

International Immunology, 2008
IL-33 is an IL-1 family member recently identified as the ligand for T1/ST2 (ST2), a member of the IL-1 receptor family. ST2 is stably expressed on mast cells and T(h)2 effector T cells and its function has been studied in the context of T(h)2-associated
M. Smithgall, M. Comeau, B. P. Yoon, D. Kaufman, R. Armitage, Dirk E. Smith   +5 more
semanticscholar   +1 more source

Parasite excretory-secretory products and their effects on metabolic syndrome [PDF]

, 2017
Obesity, one of the main causes of metabolic syndrome (MetS), is an increasingly common health and economic problem worldwide, and one of the major risk factors for developing type 2 diabetes and cardiovascular disease. Chronic, low-grade inflammation is
Crowe, J., Harnett, M.M., Harnett, W., Lumb, F.E.   +3 more
core   +2 more sources

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source