Results 91 to 100 of about 4,912,109 (290)

IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype [PDF]

, 2002
Background"Alternatively-activated" macrophages are found in Th2-mediated inflammatory settings such as nematode infection and allergic pulmonary inflammation.
Nair, Meera G, P'ng Loke, John Parkinson, Parkinson, John, Judith E Allen, Loke, P'ng, Blaxter, Mark, Meera G Nair, Guiliano, David, Mark Blaxter, Allen, Judith E, David Guiliano, Blaxter, M., Allen, J.E., Guiliano, D.B., Loke, P., Parkinson John, Parkinson, J., Allen Judith E, Blaxter Mark, Nair, M.G., Guiliano David, Nair Meera G, Loke P'ng   +23 more
core   +1 more source

Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target

Advanced Science, EarlyView.
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen, Pingmei Huang, Ruizhi Tao, Fenfen Ji, Qinyao Wei, Lok Hin Ko, Lianxin Zhou, Huarong Chen, Alvin Cheung, Wei Kang, Ko Fai To, Jun Yu, Chi Chun Wong   +12 more
wiley   +1 more source

Targeting CXCR1/2 suppresses TH2/TH17 cell responses and inhibits dual-pathology allergic lung inflammation

Journal of Allergy and Clinical Immunology: Global
Background: Many chronic inflammatory diseases are driven by TH2 and TH17 immune responses and represent a major public health burden. While monoclonal antibodies against individual TH2 or TH17 cytokines or receptors show clinical benefit, their efficacy
Koa Hosoki, MD, PhD, Annamalai Govindhan, PhD, John M. Knight, PhD, Sanjiv Sur, MD   +3 more
doaj   +1 more source

IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells.

PLoS Pathogens, 2015
Parasitic helminths establish chronic infections in mammalian hosts. Helminth/Plasmodium co-infections occur frequently in endemic areas. However, it is unclear whether Plasmodium infections compromise anti-helminth immunity, contributing to the ...
Stephanie M Coomes, Victoria S Pelly, Yashaswini Kannan, Isobel S Okoye, Stephanie Czieso, Lewis J Entwistle, Jimena Perez-Lloret, Nikolay Nikolov, Alexandre J Potocnik, Judit Biró, Jean Langhorne, Mark S Wilson   +11 more
doaj   +1 more source

The effects of GATA3 knockdown on the gene expression of Th2-1^st, Th2-4^th and memory Th2 cells.

, 2013
The effects of GATA3 knockdown on effector Th2-1st (A), Th2-4th (B) and memory Th2 cells (C) were determined with qRT-PCR. The relative expression (GATA3/Control siRNA) levels are shown.
Hitoshi Tanaka (423113), Yutaka Suzuki (1379), Shu Horiuchi (423111), Hiroyuki Hosokawa (46662), Toshinori Nakayama (46666), Atsushi Onodera (423109), Junji Yamashita (423112), Yasumasa Ogawa (423114), Tetsuya Sasaki (423108), Yukiko Watanabe (423110)   +9 more
core   +1 more source

SAT1‐Induced Spermidine Depletion Potentiates Food Allergy

Advanced Science, EarlyView.
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Manman Liu, Beiyu Zhang, Junjuan Wang, Yue Jiang, Shiwen Han, Qianwei Wang, Lingyu Zeng, Jinfeng Wang, Huilian Che   +8 more
wiley   +1 more source

Platycodon grandiflorus–Derived Nanovesicles Sensitize Gastric Cancer to T Cell Killing via Ferroptosis‐Driven Membrane Mechanical Remodeling

Advanced Science, EarlyView.
Plant‐derived nanovesicles from Platycodon grandiflorus act as bioactive lipid delivery platforms that transport γ‐linolenic acid into gastric cancer cells. This lipid cargo promotes ferroptotic lipid peroxidation, remodels membrane mechanics, and increases tumor‐cell susceptibility to cytotoxic T‐cell attack.
Jian Wu, Ruijuan Zhang, Yixin Duan, Shuqi Huo, Xiang Zhang, Yibin Xing, Lingjing Ma, Tiran Jiang, Xingyu Chen, Qingmin Sun   +9 more
wiley   +1 more source

Coinhibitory Molecule VISTA Play an Important Negative Regulatory Role in the Immunopathology of Bronchial Asthma

Journal of Asthma and Allergy
Jianqun Yin,* Jiawei Chen,* Ting Wang, Huiming Sun, Yongdong Yan, Canhong Zhu, Li Huang, Zhengrong Chen Respiratory Department, Children’s Hospital of Soochow University, Suzhou, People’s Republic of China*These authors contributed equally to
Yin J, Chen J, Wang T, Sun H, Yan Y, Zhu C, Huang L, Chen Z   +7 more
doaj  

SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian, Teizo Yoshimura, Kun Zhao, Chunning Li, Tong Gao, Ziyi Wang, Masayoshi Fujisawa, Toshiaki Ohara, Akihiro Matsukawa   +8 more
wiley   +1 more source

The immunomodulatory properties of helminth-derived products on dendritic cell maturation and function [PDF]

, 2009
Parasitic worms and molecules derived from them drive Th2/Treg immune responses in mammalian hosts and have powerful anti-inflammatory properties which are shown to have therapeutic effects on inflammatory diseases.
Dowling, David J.
core   +2 more sources