Advanced Science, Volume 12, Issue 11, March 20, 2025.This study develops an integrated platform for real‐time, on‐the‐fly imaging of focused ultrasound‐induced cell ablation and responses at cellular and subcellular levels. It reveals that focused ultrasound could induce cellular mechanolysis through subcellular cavitation bubbles growing under confined contact with cells.
Ziyue Bai, Zaimeng Li, Yue Shao
wiley +1 more source
Retinoic Acid-Related Orphan Receptor α Is Required for Generation of Th2 Cells in Type 2 Pulmonary Inflammation. [PDF]
J Immunol, 2023 Roberts J +7 more
europepmc +1 more source
Advanced Science, EarlyView.Hypoxic and low‐glucose conditions in tumor tissues trigger colorectal tumor cell pyroptosis via sequential activation of the Caspase‐1/Caspase‐6/GSDMC axis. High mobility group box 1 (HMGB1), released from GSDMC‐mediated pyroptotic tumor cells, upregulates CXCL2 expression in adjacent tumor cells, thereby recruiting myeloid‐derived suppressor cells ...
Hanchao Gao +11 more
wiley +1 more source
Distinct cytokine patterns in Occult Hepatitis C and Chronic Hepatitis C Virus Infection [PDF]
, 2011 Background & Aim: The immunopathogenesis of chronic hepatitis C virus (HCV) infection is a matter of great controversy. The imbalance of T-helper lymphocyte cell cytokine production was believed to play an important pathogenic role in ...
Azza Azza Abdel-Aziz +5 more
core +1 more source
The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells. [PDF]
Proc Natl Acad Sci U S A, 2023 Kumagai J +19 more
europepmc +1 more source
UnPaSt: unsupervised patient stratification by differentially expressed biclusters in omics data [PDF]
arXivMost complex diseases, including cancer and non-malignant diseases like asthma, have distinct molecular subtypes that require distinct clinical approaches. However, existing computational patient stratification methods have been benchmarked almost exclusively on cancer omics data and only perform well when mutually exclusive subtypes can be ...
arxiv
NETs‐CD44‐IL‐17A Feedback Loop Drives Th17‐Mediated Inflammation in Behçet's Uveitis
Advanced Science, Volume 12, Issue 16, April 24, 2025.In experimental autoimmune uveitis (EAU), neutrophils interact with T helper 17 (Th17) cells through neutrophil extracellular traps (NETs) to exert a pro‐inflammatory effect. In vitro and in vivo experiments identify that NETs promote IL‐17A secretion in Th17 cells via CD44, and increasing IL‐17A further induces more NETs formation.
Yi Wu +11 more
wiley +1 more source
Elevated profiles of peripheral Th22, Th17, Th2 cells, and decreased percentage of Th1 cells in breast cancer patients. [PDF]
Thorac Cancer, 2023 Peng Z +9 more
europepmc +1 more source
Cell mechanics, environmental geometry, and cell polarity control cell-cell collision outcomes [PDF]
arXivInteractions between crawling cells, which are essential for many biological processes, can be quantified by measuring cell-cell collisions. Conventionally, experiments of cell-cell collisions are conducted on two-dimensional flat substrates, where colliding cells repolarize and move away upon contact with one another in "contact inhibition of ...
arxiv
Transplacental Priming of the Human Immune System to Environmental Allergens: Universal Skewing of Initial T Cell Responses Toward the Th2 Cytokine Profile [PDF]
, 1998 Susan L. Prescott +6 more
openalex +1 more source