Results 241 to 250 of about 4,589,213 (294)
Some of the next articles are maybe not open access.
Th2 Cells in Health and Disease
Annual Review of Immunology, 2017Helper T (Th) cell subsets direct immune responses by producing signature cytokines. Th2 cells produce IL-4, IL-5, and IL-13, which are important in humoral immunity and protection from helminth infection and are central to the pathogenesis of many allergic inflammatory diseases.
Damon Tumes +2 more
exaly +4 more sources
Current Opinion in Hematology, 2001
After activation, CD4 helper T (Th) cells differentiate into Th1or Th2 effector subsets. These two types of cells produce distinct profiles of cytokines and regulate different immune responses. This review summarizes recent progress on different features of co-stimulatory regulation and chemokine-mediated homing of Th1 and Th2 cells.
C, Dong, R A, Flavell
openaire +2 more sources
After activation, CD4 helper T (Th) cells differentiate into Th1or Th2 effector subsets. These two types of cells produce distinct profiles of cytokines and regulate different immune responses. This review summarizes recent progress on different features of co-stimulatory regulation and chemokine-mediated homing of Th1 and Th2 cells.
C, Dong, R A, Flavell
openaire +2 more sources
TH2 cell development and function
Nature Reviews Immunology, 2017T helper 2 (TH2) cells orchestrate protective type 2 immune responses, such as those that target helminths and facilitate tissue repair, but also contribute to chronic inflammatory diseases, such as asthma and allergy. Here, we review recent insights into how diverse molecular signals from cellular sources, including dendritic cells, innate lymphoid ...
Jennifer A, Walker, Andrew N J, McKenzie
openaire +2 more sources
TH2 and ‘TH2-like’ cells in allergy and asthma: pharmacological perspectives
Trends in Pharmacological Sciences, 1994Recently, considerable progress has been made in understanding the molecular basis by which cytokines released from CD4+ helper T cells contribute to allergic disease. A subset of CD4+ helper T cells, termed TH2 cells, produce interleukin 4 (IL-4) and IL-5, but not interferon gamma.
G P, Anderson, A J, Coyle
openaire +2 more sources
1996
Markers of TH1 and TH2 lymphocyte subpopulations.
ALMERIGOGNA, FABIO +3 more
openaire +4 more sources
Markers of TH1 and TH2 lymphocyte subpopulations.
ALMERIGOGNA, FABIO +3 more
openaire +4 more sources
Inflammatory Bowel Diseases, 1999
A large body of evidence indicates the existence of functionally polarized CD4+ T-cell responses based on their profile of cytokine secretion. Type 1 T helper (Th1) cells produce interferon-gamma, interleukin (IL)-2, and tumour necrosis factor (TNF)-beta, which activate macrophages and are responsible for cell-mediated immunity and phagocyte-dependent ...
openaire +2 more sources
A large body of evidence indicates the existence of functionally polarized CD4+ T-cell responses based on their profile of cytokine secretion. Type 1 T helper (Th1) cells produce interferon-gamma, interleukin (IL)-2, and tumour necrosis factor (TNF)-beta, which activate macrophages and are responsible for cell-mediated immunity and phagocyte-dependent ...
openaire +2 more sources
An Update on Human Th1 and Th2 Cells
International Archives of Allergy and Immunology, 2009The existence of functionally polarized human T cell responses based on their profile of cytokine secretion in both the CD4+ T helper (Th) and the CD8+ T cytotoxic cell subset has been established. Human Th1 and Th2 cells not only produce a different set of cytokines but also exhibit distinct functional properties and preferential expression of some ...
ROMAGNANI, SERGIO +11 more
openaire +6 more sources
Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice
Inflammation Research, 2021Histamine derived from mast cells and basophils plays important roles in inducing allergic symptoms. Although T cells also produce histamine, the involvement of the histamine produced from T cells has remained enigmatic. We sought to reveal the roles of T helper 2 (Th2) cell-derived histamine in nasal allergic disorders.The histamine production from ...
Naruhito Iwasaki +6 more
openaire +2 more sources
Targeting Th2 Cells in Asthmatic Airways
Current Drug Target -Inflammation & Allergy, 2004The most effective anti-asthmatic drugs currently available include inhaled beta2-agonists and glucocorticoids and control asthma in about 95% of patients. The current asthma therapies are not cures and symptoms return soon after the treatment is stopped even after long-term therapy.
Gaetano, Caramori +2 more
openaire +2 more sources
Initiation and maintenance of Th2 cell identity
Current Opinion in Immunology, 2008T helper type 2 (Th2) cells produce IL-4, IL-5, and IL-13 and play an important role in humoral immunity and allergic reactions. During Th2 cell differentiation, naïve CD4 T cells acquire 'Th2 cell identity', that is, the capability to produce selectively a large amount of Th2 cytokines. Th2 cell identity is maintained in memory Th2 cells.
Toshinori, Nakayama +1 more
openaire +2 more sources