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Th2 Cells: Orchestrating Barrier Immunity
2004Publisher Summary This chapter summarizes recent insights regarding the generation of T helper (Th) 2 cells and factors regulating expression of IL-4—the canonical cytokine secreted by these cells. Th2 cells orchestrate a stereotyped cell response characterized by eosinophil and basophil infiltration, mast cell hyperplasia, and changes in epithelial ...
Daniel B, Stetson +7 more
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Biology of human TH1 and TH2 cells
Journal of Clinical Immunology, 1995Evidence is accumulating to suggest the existence of polarized human T-cell responses, reminiscent of TH1 and TH2 subsets described for mouse T cells. Human TH1 cells preferentially develop during infections by intracellular bacteria and trigger phagocyte-mediated host defense, whereas TH2 cells, which predominate during helminthic infestations and in ...
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Targeting Th2 Cells in Asthmatic Airways
2010Asthma represents a profound worldwide public health problem. The most effective anti-asthmatic drugs currently available include inhaled β2 -agonists and glucocorti-coids; these control asthma in about 90–95% of patients. However, the future therapies will need to focus on the 5–10% patients who do not respond well to these treatments and who account ...
CARAMORI, Gaetano +5 more
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Targeting Th2 cells in asthmatic patients.
2004The most effective anti-asthmatic drugs currently available include inhaled beta2-agonists and glucocorticoids and control asthma in about 95% of patients. The current asthma therapies are not cures and symptoms return soon after the treatment is stopped even after long-term therapy.
CARAMORI, Gaetano, ITO K, ADCOCK IM
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Dopamine primes TH2 cells in the lungs
Journal of Allergy and Clinical Immunology, 2023Derek J, Bangs, Marion, Pepper
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IL-6 prevents Th2 cell polarization by promoting SOCS3-dependent suppression of IL-2 signaling
Cellular and Molecular Immunology, 2023Amber M Papillion +2 more
exaly
New advances on human TH1 and TH2 cells
1994HUMAN TH1 AND TH2 ...
ROMAGNANI, SERGIO +12 more
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