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Current Opinion in Hematology, 2001
After activation, CD4 helper T (Th) cells differentiate into Th1or Th2 effector subsets. These two types of cells produce distinct profiles of cytokines and regulate different immune responses. This review summarizes recent progress on different features of co-stimulatory regulation and chemokine-mediated homing of Th1 and Th2 cells.
C, Dong, R A, Flavell
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After activation, CD4 helper T (Th) cells differentiate into Th1or Th2 effector subsets. These two types of cells produce distinct profiles of cytokines and regulate different immune responses. This review summarizes recent progress on different features of co-stimulatory regulation and chemokine-mediated homing of Th1 and Th2 cells.
C, Dong, R A, Flavell
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Inflammatory Bowel Diseases, 1999
A large body of evidence indicates the existence of functionally polarized CD4+ T-cell responses based on their profile of cytokine secretion. Type 1 T helper (Th1) cells produce interferon-gamma, interleukin (IL)-2, and tumour necrosis factor (TNF)-beta, which activate macrophages and are responsible for cell-mediated immunity and phagocyte-dependent ...
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A large body of evidence indicates the existence of functionally polarized CD4+ T-cell responses based on their profile of cytokine secretion. Type 1 T helper (Th1) cells produce interferon-gamma, interleukin (IL)-2, and tumour necrosis factor (TNF)-beta, which activate macrophages and are responsible for cell-mediated immunity and phagocyte-dependent ...
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Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice
Inflammation Research, 2021Histamine derived from mast cells and basophils plays important roles in inducing allergic symptoms. Although T cells also produce histamine, the involvement of the histamine produced from T cells has remained enigmatic. We sought to reveal the roles of T helper 2 (Th2) cell-derived histamine in nasal allergic disorders.The histamine production from ...
Naruhito Iwasaki +6 more
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Targeting Th2 Cells in Asthmatic Airways
Current Drug Target -Inflammation & Allergy, 2004The most effective anti-asthmatic drugs currently available include inhaled beta2-agonists and glucocorticoids and control asthma in about 95% of patients. The current asthma therapies are not cures and symptoms return soon after the treatment is stopped even after long-term therapy.
Gaetano, Caramori +2 more
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Th2 Cells: Orchestrating Barrier Immunity
2004Publisher Summary This chapter summarizes recent insights regarding the generation of T helper (Th) 2 cells and factors regulating expression of IL-4—the canonical cytokine secreted by these cells. Th2 cells orchestrate a stereotyped cell response characterized by eosinophil and basophil infiltration, mast cell hyperplasia, and changes in epithelial ...
Daniel B, Stetson +7 more
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1996
Markers of TH1 and TH2 lymphocyte subpopulations.
ALMERIGOGNA, FABIO +3 more
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Markers of TH1 and TH2 lymphocyte subpopulations.
ALMERIGOGNA, FABIO +3 more
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Crossregulation Between Th1 and Th2 Cells
Critical Reviews™ in Immunology, 1998Th1 and Th2 subsets have been characterized on the basis of the cytokines they secrete and the immune functions they mediate. Th1 cells secrete IL-2, IFN-gamma, and lymphotoxin and are important in the cell-mediated response; Th2 cells secrete IL-4, IL-5, IL-10, and IL-13 and are important in the control of macrophage function and in the stimulation of
P A, Morel, T B, Oriss
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TH2 and ‘TH2-like’ cells in allergy and asthma: pharmacological perspectives
Trends in Pharmacological Sciences, 1994Recently, considerable progress has been made in understanding the molecular basis by which cytokines released from CD4+ helper T cells contribute to allergic disease. A subset of CD4+ helper T cells, termed TH2 cells, produce interleukin 4 (IL-4) and IL-5, but not interferon gamma.
G P, Anderson, A J, Coyle
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Targeting Th2 Cells in Asthmatic Airways
2010Asthma represents a profound worldwide public health problem. The most effective anti-asthmatic drugs currently available include inhaled β2 -agonists and glucocorti-coids; these control asthma in about 90–95% of patients. However, the future therapies will need to focus on the 5–10% patients who do not respond well to these treatments and who account ...
CARAMORI, Gaetano +5 more
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