Results 161 to 170 of about 255,451 (370)

Practical management of repeated life‐threatening status epilepticus in Alternating Hemiplegia of Childhood: Case report and literature review

open access: yesEpileptic Disorders, EarlyView.
Abstract Background Alternating Hemiplegia of Childhood (AHC) is a severe channelopathy that manifests before 18 months of age, primarily caused by pathogenic variants in the ATP1A3 gene. It is characterized by recurrent and disabling episodes of plegia, dystonia, dysautonomia, along with chronic neurological features and cardiac arrhythmias. About 50%
Ramona Cordani   +8 more
wiley   +1 more source

Co‐occurrence of childhood absence epilepsy and self‐limited focal epilepsy interictal discharges: Differences from childhood absence epilepsy alone

open access: yesEpileptic Disorders, EarlyView.
Abstract Objective Some children with Childhood Absence Epilepsy (CAE) exhibit focal abnormalities similar to those observed in Self‐Limited Focal Epilepsies of Childhood (SeLFEs). It remains unclear whether this subgroup of patients may present distinct clinical characteristics or prognoses compared to those with CAE and generalized discharges alone ...
Giulia Barbagallo   +6 more
wiley   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

open access: yesEpilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Intracranial stimulation for pediatric refractory epilepsy: A single institutional experience using evolving therapies

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Neuromodulation for pediatric refractory epilepsy (PRE) is preferred when the seizure onset zone is not amenable to surgical resection, due to multifocal onset or involvement of eloquent cortex. Given its rapidly evolving landscape, we describe our institutional experience with neurostimulation therapies including deep brain ...
Rohin Singh   +9 more
wiley   +1 more source

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

open access: yesEpilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

Decreased homovanillic acid and 5‐hydroxyindoleacetic acid levels in the cerebrospinal fluid of patients with Dravet syndrome with parkinsonism

open access: yesEpilepsia Open, EarlyView.
Abstract Dravet syndrome (DS) is an early onset, developmental, and epileptic encephalopathy characterized by drug‐resistant seizures and multiple comorbidities. It has been reported that in adulthood, it may be accompanied by parkinsonism, but the pathogenesis of this condition remains unclear.
Ryo Sugiyama   +5 more
wiley   +1 more source

RATNUS: Rapid, Automatic Thalamic Nuclei Segmentation using Multimodal MRI inputs [PDF]

open access: yesarXiv
Accurate segmentation of thalamic nuclei is important for better understanding brain function and improving disease treatment. Traditional segmentation methods often rely on a single T1-weighted image, which has limited contrast in the thalamus. In this work, we introduce RATNUS, which uses synthetic T1-weighted images with many inversion times along ...
arxiv  

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