Results 111 to 120 of about 158,916 (259)

Epidemiological and comorbidity burden in transfusion-dependent patients with thalassemia and sickle cell disease in Greece

Annals of Hematology
TDT and SCD are hereditary hemoglobinopathies that require lifelong red blood cell transfusions. Modern treatment has increased survival, exposing patients to transfusion-related problems such iron excess.
Sophia Delicou, Aikaterini Xydaki, Vassiliki Kamposou, Sabrina Goga, Anthimos Papadopoulos, Christina Rina, Maria Moraki   +6 more
doaj   +1 more source

Thalassemia and Hemoglobin E in Southern Thai Blood Donors

Advances in Hematology, 2014
Thalassemia and hemoglobin E (Hb E) are common in Thailand. Individuals with thalassemia trait usually have a normal hemoglobin concentration or mild anemia. Therefore, thalassemic individuals who have minimum acceptable Hb level may be accepted as blood
Manit Nuinoon, Kwanta Kruachan, Warachaya Sengking, Dararat Horpet, Ubol Sungyuan   +4 more
doaj   +1 more source

Effect of zinc supplementation on serum mlondealdehyde and lipid profiles on beta thalassemia major patients [PDF]

, 2012
Objectives: Thalassemic patients are seriously at risk of serum dislipidemia, zinc deficiency and tissue damage due to oxidative stress induced by iron storage.
Aboomardani, M., Arefhosseini, R., Rafraf, M., Rashidi, M.R.   +3 more
core  

Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders

The FEBS Journal, EarlyView.
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo, Bastien Morlet, Luc Negroni, Orsolya Mózner, Balázs Sarkadi, Gilles Travé, Gergo Gogl   +6 more
wiley   +1 more source

The emerging role of non-coding RNAs in the pathogenesis of infantile hemangioma

Cancer Cell International
Infantile hemangioma (IH) is a common benign tumor that occurs in children, affecting both blood vessels and soft tissues. Its pathological features include abnormal proliferation of endothelial cells and an irregular vascular structure.
Najmaldin Saki, Narjes Sadat Sadati, Zeinab Deris Zayeri, Masoud Kargar   +3 more
doaj   +1 more source

Thalassemia intermedia.

Haematologica, 1995
Thalassemia intermedia is a clinical definition applied to patients whose clinical phenotype is milder than that of thalassemia major. Criteria used to define thalassemia intermedia including age at presentation, hemoglobin or fetal hemoglobin levels and transfusion independence, are unsatisfactory. The possibility of typing the molecular defect allows
C. Camaschella, M.D. Cappellini
openaire   +2 more sources

National Bleeding Disorder Foundation Clinical Practice Recommendations for Laboratory Screening of Iron Deficiency With and Without Anemia in the Inherited Bleeding Disorders Population

Haemophilia, EarlyView.
ABSTRACT Introduction The National Bleeding Disorder Foundation (NBDF) Medical and Scientific Advisory Council (MASAC) was formed in 1954 and issues recommendations and advisories pertinent to the bleeding disorders community. MASAC is comprised of > 25 rotating members from different medical disciplines and lived experience experts.
Glaivy Batsuli, Magdalena D. Lewandowska, Ming Y. Lim, Kelly Tickle, Maureen K. Baldwin, Rose Bender, Jennifer Davila, Brendan Hayes, Amanda Jacobson‐Kelly, Peter Kouides, Michele P. Lambert, Shilpa Nataraj, Michelle Sholzberg, Roona Sinha, Hanny Al‐Samkari, Amy L. Dunn   +15 more
wiley   +1 more source

No Difference in Health Related Quality of Life Between Therapeutic Options for Type 1 Gaucher Disease [PDF]

, 2016
Type 1 Gaucher disease (GD) is the most common lysosomal storage disorder. Previously, treatment for GD was limited to intravenous enzyme replacement therapy (ERT).
Wagner, Victoria
core   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Enhanced induction of fetal hemoglobin by the combination of decitabine with RN-1 in β-thalassemia/HbE erythroid progenitor cells

Molecular Medicine
Background Fetal hemoglobin (HbF; α2γ2) induction is a well-established approach for β-hemoglobinopathies, including sickle cell disease (SCD) and β-thalassemia.
Tiwaporn Nualkaew, Phitchapa Pongpaksupasin, Thongperm Munkongdee, Nattrika Buasuwan, Kittiphong Paiboonsukwong, Orapan Sripichai, James Douglas Engel, Suradej Hongeng, Suthat Fucharoen, Natee Jearawiriyapaisarn   +9 more
doaj   +1 more source