Results 121 to 130 of about 114,325 (234)

Correction of Ineffective Erythropoiesis and Normalization of Iron Homeostasis After Exagamglogene Autotemcel in Transfusion‐Dependent β‐Thalassemia

American Journal of Hematology, Volume 101, Issue 8, Page 1969-1979, August 2026.
ABSTRACT Exagamglogene autotemcel (exa‐cel) is a one‐time, ex vivo, CRISPR‐Cas9 gene edited cell therapy approved for patients with transfusion dependent β‐thalassemia (TDT) aged 12–35 years. In a Phase 3 study (CLIMB THAL‐111), exa‐cel treatment resulted in reactivation of fetal hemoglobin and increases in total hemoglobin, leading to transfusion ...
Sujit Sheth, Selim Corbacioglu, Josu de la Fuente, Mattia Algeri, Joachim Rupprecht, Kevin H. M. Kuo, Ami J. Shah, Peter Lang, Hayley Merkeley, Ben Carpenter, Markus Y. Mapara, Robert I. Liem, Stephan Grupp, Yogi Chopra, Amanda M. Li, Janet L. Kwiatkowski, Melanie Kirby‐Allen, Maria Domenica Cappellini, Antonis Kattamis, Sakellarios Zairis, Tina Liu, William Hobbs, Haydar Frangoul, Franco Locatelli, Roland Meisel, on behalf of the CLIMB THAL‐111 and CLIMB‐131 Study Groups   +25 more
wiley   +1 more source

A Prospective Multi-Center Newborn Screening for Thalassemia by Comprehensive Analysis of Thalassemia Alleles (CATSA) Based on Single Molecule Real-Time Sequencing in Guangxi, China. [PDF]

Int J Neonatal Screen
Xia A, Chen H, Lu F, Xu P, Shen P, Wei W, Gui C, Liu J, Wei D, Qin H, Huang Y, Long J, Gui B.   +12 more
europepmc   +1 more source

A Rare Diagnosis of Dubin‐Johnson Syndrome During Pregnancy: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Dubin‐Johnson Syndrome (DJS) is a rare inherited disorder characterized by isolated conjugated hyperbilirubinemia without significant liver damage. This syndrome is often diagnosed incidentally during routine blood tests, as it typically presents with minimal or no symptoms.
Said Reza Modares Mousavi, Farab Pourhasan, Pouria Ahmadi Simab, Sepideh Beikmohammadi‐Gharehsaghghal, Daryoush Kaini‐Shamsabadi, Elaheh Karimzadeh‐Soureshjani   +5 more
wiley   +1 more source

Thalassemia in Guangxi: current situation and future prospects. [PDF]

Front Public Health
Liang L, He S.
europepmc   +1 more source

Knowledge, Attitudes and Practices Toward Hepatitis B Virus Among Transfusion‐Dependent Thalassemia Patients in Jordan

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Knowledge, attitudes, and practices (KAP) studies provide essential insight into public awareness, perceptions, and behaviors toward health issues. Hepatitis B virus (HBV) remains a major public health problem in Jordan. Transfusion‐dependent patients are at higher risk of infection due to frequent exposure to blood products.
Nader Alaridah, Haneen O. Abuhani, Rahaf A. Jereisat, Sara Abu‐Mutaw, Raba'a F. Jarrar, Rayan M. Joudeh, Hasan Nassr, Layan Ismail, Haneen Al‐Abdallat, Anas Y. El‐Massad, Heba Mahmmoud, Anas H. A. Abu‐Humaidan   +11 more
wiley   +1 more source

Validation of Gazelle Microchip Electrophoresis for Premarital Hemoglobinopathy Screening in Türkiye. [PDF]

EJHaem
Canatan D, Delibaş S, Altunsoy E, Gökkaya EG, Aydın S, Tuncel DA, Natu R, Thota P, Gurkan UA.   +8 more
europepmc   +1 more source

Sickle Cell Disease and Kidney Injury: Circulating Uromodulin Allows Early Tissue Specific Diagnosis and Monitoring of Treatment

American Journal of Hematology, Volume 101, Issue 9, Page 2430-2434, September 2026.
Ferras Alashkar, Robert Hable, Denise Zwanziger, Friederike Poppenborg, Raina Yamamoto, Hans Christian Reinhardt, Alexander Röth, Victor Herbst, Yara Bestmann, Marco Kai, Jürgen E. Scherberich   +10 more
wiley   +1 more source

Mutation Spectrum of Hemoglobinopathies in Tunisia. [PDF]

Hum Mutat
Moumni I, Khalfaoui K, Chebbi M, Chaouch L, Ouragini H, Chaouechi D, Mellouli F, Ouederni M, Benkhaled M, Abbes S, Menif S.   +10 more
europepmc   +1 more source

Cross Sectional Study of Prenatal Diagnosis Uptake Among Individuals With Genetic Conditions

Prenatal Diagnosis, Volume 46, Issue 9, Page 1374-1384, August 2026.
ABSTRACT Objective Prenatal diagnostic genetic testing allows for early identification of significant fetal conditions and enables informed decision‐making regarding management options. The aim of this study was to assess prenatal testing practice among individuals with genetic conditions.
Ebunoluwa Ojo, Roni Zemet, Allyson Nevins, Katherine Abraham, April D. Adams   +4 more
wiley   +1 more source

Screening for β-Thalassemia Trait in Pregnant Women With Microcytic Hypochromic Anemia and Its Impact on Pregnancy Outcomes. [PDF]

Cureus
Bamrah D, Nautiyal R, Kala M, Bhat K, Garg S.   +4 more
europepmc   +1 more source