Results 121 to 130 of about 181,456 (327)
Diagnostic error reduction in the United States and Italy through the intervention of diagnostic management teams [PDF]
, 2018 A major challenge to most countries is the growing cost of healthcare. The cost of laboratory testing is approximately 3% of the total clinical costs.
Adriana Berumen Velazquez +2 more
core
An oral treatment for iron overload in thalassemia? [PDF]
, 1996 Kris V. Kowdley, Anthony S. Tavill
openalex +1 more source
Expression of γ-globin genes in β-thalassemia patients treated with sirolimus: results from a pilot clinical trial (Sirthalaclin) [PDF]
, 2022 Cristina Zuccato +17 more
openalex +1 more source
Making Advanced Therapies Affordable and Accessible: Two Strategic Approaches
Developing World Bioethics, EarlyView.ABSTRACT This article explores two complementary strategies for addressing the affordability and access challenges facing advanced therapies. As high development costs and limited market access have led to the withdrawal of several therapies, the article examines how these barriers create ‘valleys of death’ that prevent innovation from reaching ...
Ubaka Ogbogu, Lauren Albrecht
wiley +1 more source
European Journal of Haematology, EarlyView.ABSTRACT Objectives Although Advancements in the Treatment of Hemoglobinopathies have Considerably Increased Life Expectancy, Hormonal and Pubertal Development Have Been Continuously Affected by Complications From Transfusion‐Related Iron Overload and Cytotoxic Therapies.
J. Dülberg +20 more
wiley +1 more source
Whole Blood Transcriptomic Analysis of Sickle Cell Trait
European Journal of Haematology, EarlyView.ABSTRACT Sickle cell trait (SCT) is the heterozygous carrier state for the HBB missense variant which causes sickle cell disease (SCD). SCT has been associated with increased risk of venous thromboembolism and chronic kidney disease as well as alterations in clinical laboratory parameters. To investigate differential gene expression in SCT, we used RNA
Mari Johnson +12 more
wiley +1 more source
Reduction of Oxidative Stress and Storage Lesions (RCSL) in Red Blood Cells: Analysis of Ascorbic Acid (AA), N-Acetylcysteine amide (AD4), and Serotonin (5-HT) [PDF]
, 2018 Oxidative stress is a common occurrence in red blood cell (RBC) storage in blood banks throughout the world. Typically RBC units stored under routine standard protocol (stored in SAGM-CPD additive solution) can only be kept up to forty-two days for ...
Gadiraju, Shanmuka
core +1 more source
Cas9 beyond CRISPR – SUMOylation, effector‐like potential and pathogenic adaptation
The FEBS Journal, EarlyView.This Viewpoint explores the possibility that Cas9, beyond its canonical role in CRISPR immunity, may act as a host‐modulating effector during infection by Cas9‐encoding bacteria. Such a nucleomodulin‐like function could be influenced by eukaryotic post‐translational modifications, particularly SUMOylation, with potential implications for host–pathogen ...
Umut Sahin
wiley +1 more source
Haematologica, 1995 Thalassemia intermedia is a clinical definition applied to patients whose clinical phenotype is milder than that of thalassemia major. Criteria used to define thalassemia intermedia including age at presentation, hemoglobin or fetal hemoglobin levels and transfusion independence, are unsatisfactory. The possibility of typing the molecular defect allows
C. Camaschella, M.D. Cappellini
openaire +2 more sources