Results 11 to 20 of about 107,712 (298)
Genetics in Medicine, 2016 β-Thalassemia is caused by reduced (β+) or absent (β0) synthesis of the β-globin chains of hemoglobin. Three clinical and hematological conditions of increasing severity are recognized: the β-thalassemia carrier state, thalassemia intermedia, and thalassemia major, a severe transfusion-dependent anemia.
R. Origa
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Genetics in Medicine, 2023 Beta-thalassemia is caused by the reduced (beta+) or absent (beta0) synthesis of the beta globin chains of the hemoglobin tetramer. Three clinical and hematological conditions of increasing severity are recognized, i.e., the beta-thalassemia carrier ...
A. Cao, R. Galanello
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American journal of hematology/oncology, 2023 This systematic literature review assessed the global prevalence and birth prevalence of clinically significant forms of alpha‐ and beta‐thalassemia. Embase, MEDLINE, and the Cochrane Library were searched for observational studies published January 1 ...
K. Musallam +8 more
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HemaSphere, 2022 Beta-thalassemia and particularly its transfusion-dependent form (TDT) is a demanding clinical condition, requiring life-long care and follow-up, ideally in specialized centers and by multidisciplinary teams of experts.
D. Farmakis +5 more
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Cardiovascular Complications in β-Thalassemia: Getting to the Heart of It
Thalassemia Reports, 2023 Beta thalassemia is an inherited disorder resulting in abnormal or decreased production of hemoglobin, leading to hemolysis and chronic anemia. The long-term complications can affect multiple organ systems, namely the liver, heart, and endocrine ...
Nathalie Akiki +4 more
semanticscholar +1 more source
Orphanet Journal of Rare Diseases, 2010 Beta-thalassemias are a group of hereditary blood disorders characterized by anomalies in the synthesis of the beta chains of hemoglobin resulting in variable phenotypes ranging from severe anemia to clinically asymptomatic individuals. The total annual incidence of symptomatic individuals is estimated at 1 in 100,000 throughout the world and 1 in 10 ...
Galanello R, ORIGA, RAFFAELLA
openaire +8 more sources
Current status of beta‐thalassemia and its treatment strategies
Molecular Genetics & Genomic Medicine, 2021 Thalassemia is an inherited hematological disorder categorized by a decrease or absence of one or more of the globin chains synthesis. Beta‐thalassemia is caused by one or more mutations in the beta‐globin gene.
Shaukat Ali +11 more
semanticscholar +1 more source
Thalassemia Major and Associated Psychosocial Problems: A Narrative Review
Iranian Journal of Public Health, 2022 Thalassemia is an inherited disease that causes the production of damaged hemoglobin chains. Patients are diagnosed with thalassemia major due to major clinical signs and deep anemia.
Hazel Şahin Tarım, Fatma Öz
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Definitions, 2020 The signs and symptoms of thalassemia major appear within the first 2 years of life. Children develop life-threatening anemia. They do not gain weight and grow at the expected rate (failure to thrive) and may develop yellowing of the skin and whites of ...
Antonio Piga +3 more
semanticscholar +1 more source