Results 41 to 50 of about 107,712 (298)

Ferritin thresholds for cardiac and liver hemosiderosis in β-thalassemia patients: a diagnostic accuracy study

Scientific Reports, 2022
Ferritin is frequently used to screen some dire consequences of iron overload in β-thalassemia patients. The study aimed to define the best cutoff point of ferritin to screen for cardiac and liver hemosiderosis in these cases.
Hadi Darvishi-Khezri, Aily Aliasgharian, Mohammad Naderisorki, Mehrnoush Kosaryan, Mobin Ghazaiean, Hanie Fallah, Mohammad Zahedi, Hossein Karami   +7 more
doaj   +1 more source

Potential Effects of Silymarin and Its Flavonolignan Components in Patients with β-Thalassemia Major: A Comprehensive Review in 2015

Advances in Pharmacological Sciences, 2016
Major β-thalassemia (β-TM) is one of the most common inherited hemolytic types of anemia which is caused as a result of absent or reduced synthesis of β-globin chains of hemoglobin. This defect results in red blood cells lysis and chronic anemia that can
Hadi Darvishi Khezri, Ebrahim Salehifar, Mehrnoush Kosaryan, Aily Aliasgharian, Hossein Jalali, Arash Hadian Amree   +5 more
doaj   +1 more source

The shortcut strategy for beta thalassemia prevention

Hematology Reports, 2018
We propose antenatal blood tests using high-resolution DNA melting (HRM) analysis for beta thalassemia mutation detection after hemoglobin A2 estimation as a modified strategy for the identification of beta thalassemia at-risk couples.
Narutchala Suwannakhon, Khajohnsilp Pongsawatkul, Teerapat Seeratanachot, Khwanruedee Mahingsa, Arunee Pingyod, Wanwipa Bumrungpakdee, Torpong Sanguansermsri   +6 more
doaj   +1 more source

Let’s talk about thal: How communication can improve quality of life

Thalassemia Reports, 2018
In many parts of the world, research, improved technology, and better medicine have enabled people with thalassemia to live longer. It is tragic that due to global disparity in healthcare, in areas of the world where thalassemia is most prevalent, the ...
Laurice M. Levine
doaj   +1 more source

Identification of optimal thalassemia screening strategies for migrant populations in Thailand using a qualitative approach

BMC Public Health, 2021
Background Thalassemia is a common inherited hemoglobin disorder in Southeast Asia. Severe thalassemia can lead to significant morbidity for patients and economic strain for under-resourced health systems.
Julia Z. Xu, Meghan Foe, Wilaslak Tanongsaksakul, Thidarat Suksangpleng, Supachai Ekwattanakit, Suchada Riolueang, Marilyn J. Telen, Bonnie N. Kaiser, Vip Viprakasit   +8 more
doaj   +1 more source

Luspatercept improves hemoglobin levels and blood transfusion requirements in a study of patients with β-thalassemia.

Blood, 2019
β-thalassemia is a hereditary disorder with limited approved treatment options; patients experience anemia and its complications, including iron overload.
A. Piga, S. Perrotta, M. Gamberini, E. Voskaridou, A. Melpignano, A. Filosa, V. Caruso, A. Pietrangelo, F. Longo, I. Tartaglione, C. Borgna-Pignatti, Xiaosha Zhang, A. Laadem, M. Sherman, K. Attie   +14 more
semanticscholar   +1 more source

Thalassemia and the Heartquake

Thalassemia Reports, 2014
On May 2012 the city of Ferrara and the surrounding region were hit by several earthquakes. We had the chance to observe the behavior of one thalassemic heart during the shocks, because of a 24-h electrocardiogram recording had been put in place a few hours before the shocks.
Caterina Borgna-Pignatti, Anna Tarocco, Alessandro Baldan, Alessandro Fucili   +3 more
openaire   +5 more sources

Sickle Cell Diastolic Cardiomyopathy and Mortality Risk: A Novel Echocardiographic Framework for Prognostic Stratification

American Journal of Hematology, EarlyView.
ABSTRACT Cardiovascular complications are the leading cause of mortality in sickle cell anemia (SCA) patients. While extensive data have identified diastolic dysfunction (DD) to increase morbidity and mortality, the unique hemodynamic conditions inherent to SCA challenge the current recommendations to assess diastolic function. Thus, there is an urgent
Théo Simon, Laurent Savale, Kristoffer Grundtvig Skaarup, Paul Breillat, Luu‐Ly Pham, Seyed‐Mehdi Nouraie, Niklas Dyrby Johansen, Jocelyn Inamo, Francois Lionnet, Gylna Loko, Christelle Chantalat, Anne Laure Pham Hung d’Alexandry d’Orengiani, Anoosha Habibi, Gonzalo de Luna, Sihem Iles, Frédéric Galactéros, Etienne Audureau, Tor Biering‐Sørensen, Pablo Bartolucci, Geneviève Derumeaux, Thomas d’Humières   +20 more
wiley   +1 more source

HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THALASSEMIA AND SICKLE CELL DISEASE: EXPERIENCE OF MEDITERRANEAN INSTITUTE OF HEMATOLOGY IN A MULTI-ETHNIC POPULATION.

Mediterranean Journal of Hematology and Infectious Diseases, 2009
Hematopoietic stem cell transplantation (HSCT) still remains the only definitive cure currently available for patients with thalassemia and sickle cell anemia.
Marco Marziali, Antonella Isgrò, Javid Gaziev, Guido Lucarelli   +3 more
doaj   +1 more source

Transferrin Purification, Biophysical Characterization, and Lung Biodistribution in Sickle Cell Disease Mice

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Plasma transferrin (Tf) is the transport protein central to the process of iron recycling and metabolism. Holo‐Tf serves as the body's pool of ferric iron, facilitating transport from tissues such as the intestine, liver, spleen, and finally bone marrow, where iron is incorporated into erythropoiesis.
Shuwei Lu, Mohd A. Khan, Saini Setua, Quintin O'Boyle, Kiruphagaran Thangaraju, Pedro Cabrales, Delaney C. Swindle, David C. Irwin, Paul W. Buehler, Andre F. Palmer   +9 more
wiley   +1 more source