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Major Thalassemia, Screening or Treatment: An Economic Evaluation Study in Iran [PDF]
BackgroundBeta-thalassemia minor and thalassemia major are an autosomal recessive disease with hypochromic, microcytic anemia, and morbidities, Today, therapeutic advances have significantly improved the life expectancy of thalassemia major patients, but
Firooz Esmaeilzadeh +4 more
doaj +2 more sources
Osteoporosis in Thalassemia Major
Thalassemia Major is an inherited blood disorder which leads to ineffective erythropoiesis, bone marrow expansion, and skeletal deformity. In the last two decades the survival of the patients has improved considerably and osteoporosis has become a serious burden.
Pembe Hare Yiğitoğlu, Rengin Güzel
doaj +3 more sources
Prevalence of Candida albicans in the oral cavity of Beta Thalassemia Major and Thalassemia Minor Patients [version 2; peer review: 2 approved] [PDF]
Aims To examine the correlation between iron, ferritin concentrations, and C. albicans infection in individuals with beta-thalassemia major and beta-thalassemia minor compared with healthy subjects.
Maha Adel Mahmood +1 more
doaj +2 more sources
Background: Â-thalassemia is a common single genetic disorder in Pakistanwith about 8% gene frequency and roughly 10 million carriers. Growth impairment leadingto short stature in thalassemic patients is an important cause of morbidity. Objectives: Todetermine the frequency of short stature in children with muti-transfused â-Thalassemia major.Study ...
Muhammad Shamaoon +2 more
semanticscholar +5 more sources
The survival rate of patients with beta-thalassemia major and intermedia and its trends in recent years in Iran [PDF]
OBJECTIVES Thalassemia is a common genetic disease in Iran, especially in the north and south of Iran. The present study sought to determine the survival rate of patients with thalassemia in highly endemic regions of Iran and its variation in patients ...
Alireza Ansari-Moghaddam +4 more
doaj +2 more sources
Insulin-like growth factor-1 levels in children with Beta-thalassemia minor [PDF]
Objective: Growth retardation in children with b-thalassemia major is multifactorial. Some etiologies described for this condition are hemochromatosis, disturbed growth hormone (GH) / insulin growth factor-1 (IGF-1) axis, undernutrition and ...
Mehran Karimi +2 more
doaj +1 more source
Cardiac complications in thalassemia major
The myocardium is particularly susceptible to complications from iron loading in thalassemia major. In the first years of life, severe anemia leads to high‐output cardiac failure and death if not treated. The necessary supportive blood transfusions create loading of iron that cannot be naturally excreted, and this iron accumulates within tissues ...
Auger, D, Pennell, DJ
openaire +4 more sources
Thalassemia Major and Associated Psychosocial Problems: A Narrative Review
Thalassemia is an inherited disease that causes the production of damaged hemoglobin chains. Patients are diagnosed with thalassemia major due to major clinical signs and deep anemia.
Hazel Şahin Tarım, Fatma Öz
semanticscholar +1 more source
Background: Blood transfusion is a traditional treatment for β-thalassemia (β-thal) that improves the patients’ anemia and lifespan, but it may lead to iron overload in parenchymal tissue organs and endocrine glands that cause their dysfunctions as the ...
M. Arab-Zozani +3 more
semanticscholar +1 more source

