Results 11 to 20 of about 5,420,950 (275)

The survival rate of patients with beta-thalassemia major and intermedia and its trends in recent years in Iran [PDF]

Epidemiology and Health, 2018
OBJECTIVES Thalassemia is a common genetic disease in Iran, especially in the north and south of Iran. The present study sought to determine the survival rate of patients with thalassemia in highly endemic regions of Iran and its variation in patients ...
Alireza Ansari-Moghaddam, Hossein Ali Adineh, Iraj Zareban, Mehdi Mohammadi, Mahtab Maghsoodlu   +4 more
doaj   +2 more sources

Cardiac complications in thalassemia major

Annals of the New York Academy of Sciences, 2016
The myocardium is particularly susceptible to complications from iron loading in thalassemia major. In the first years of life, severe anemia leads to high‐output cardiac failure and death if not treated. The necessary supportive blood transfusions create loading of iron that cannot be naturally excreted, and this iron accumulates within tissues ...
Auger, D, Pennell, DJ
openaire   +5 more sources

Thalassemia Major and Associated Psychosocial Problems: A Narrative Review

Iranian Journal of Public Health, 2022
Thalassemia is an inherited disease that causes the production of damaged hemoglobin chains. Patients are diagnosed with thalassemia major due to major clinical signs and deep anemia.
Hazel Şahin Tarım, Fatma Öz
semanticscholar   +1 more source

Advances in the management of α-thalassemia major: reasons to be optimistic.

Hematology. American Society of Hematology. Education Program, 2021
α-Thalassemia major (ATM) is a severe disease resulting from deletions in all 4 copies of the α-globin gene. Although it is usually fatal before birth, the advent of in utero transfusions has enabled survival of a growing number of children.
Paulina Horvei, T. Mackenzie, S. Kharbanda   +2 more
semanticscholar   +1 more source

A Systematic Review and Meta-Analysis of Stature Growth Complications in β-thalassemia Major Patients

Annals of Global Health, 2021
Background: Blood transfusion is a traditional treatment for β-thalassemia (β-thal) that improves the patients’ anemia and lifespan, but it may lead to iron overload in parenchymal tissue organs and endocrine glands that cause their dysfunctions as the ...
M. Arab-Zozani, S. Kheyrandish, Amirhossein Rastgar, E. Miri-Moghaddam   +3 more
semanticscholar   +1 more source

The Close Link of Pancreatic Iron With Glucose Metabolism and With Cardiac Complications in Thalassemia Major: A Large, Multicenter Observational Study

Diabetes Care, 2020
OBJECTIVE We systematically explored the link of pancreatic iron with glucose metabolism and with cardiac complications in a cohort of 1,079 patients with thalassemia major (TM) enrolled in the Extension-Myocardial Iron Overload in Thalassemia (E-MIOT ...
A. Pepe, L. Pistoia, M. Gamberini, L. Cuccia, A. Peluso, G. Messina, A. Spasiano, Massimo Allò, Maria Grazia Bisconte, M. Putti, T. Casini, N. Dello Iacono, M. Celli, A. Vitucci, P. Giuliano, G. Peritore, S. Renne, R. Righi, V. Positano, V. De Sanctis, A. Meloni   +20 more
semanticscholar   +1 more source

Hepcidin gene polymorphisms and iron overload in β-thalassemia major patients refractory to iron chelating therapy

BMC Medical Genetics, 2020
Background β Thalassemia is one of the most common groups of hereditary haemoglobinopathies. Affected people with thalassemia major are dependent on regular blood transfusion which on the long term leads to iron overload.
Parinaz Zarghamian, A. Azarkeivan, A. Arabkhazaeli, A. Mardani, M. Shahabi   +4 more
semanticscholar   +1 more source

Assessment of level of Awareness regarding Thalassemia Major among Parents of Affected Children

Journal of Rawalpindi Medical College, 2021
Background: Thalassemia major is amongst the most common genetic disorders in developing countries like Pakistan. This research project aims to assess the level of knowledge among people related to thalassemia and the number of thalassemia cases linked ...
Faizan Fazal, Mateen Arshad, Haris Mustafa, Muhammad Ebad Ur Rehman, Usama Tanveer, Sidra Hamid   +5 more
doaj   +1 more source

Salivary Oxidative Stress, Total Protein, Iron and pH in Children with β-Thalassemia Major and their Correlation with Dental Caries [PDF]

Journal of Dentistry, 2022
Statement of the Problem: Iron overload in β-thalassemia major leads to oxidative damage to tissues, which may have an important role in the onset and progression of oral diseases.Purpose: The aim of this study was to evaluate the salivary oxidative ...
Ali Amin Akbarnejad, Soleiman Mahjoub, Ahmad Tamadoni, Jila Masrour-Roudsari, Seyedali Seyedmajidi, Maryam Ghasempour   +5 more
doaj   +1 more source

Beta-Thalassemia major and pregnancy

Bratislava Medical Journal, 2013
It was studied the clinical management and the medical outcomes of 6 pregnancies in 5 women affected by Beta Thalassemia major, based on last guidelines and pharmacological treatments.Paediatric Department and Department of Obstetrics and Gynaecology of the University of Catania.These patients were taken among a group of 116 women affected by beta ...
Gulino F. A., Vitale S. G., Fauzia M., Cianci S., Pafumi C., Palumbo M. A.   +5 more
openaire   +8 more sources