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Advances in the management of α-thalassemia major: reasons to be optimistic.
Hematology. American Society of Hematology. Education Program, 2021 α-Thalassemia major (ATM) is a severe disease resulting from deletions in all 4 copies of the α-globin gene. Although it is usually fatal before birth, the advent of in utero transfusions has enabled survival of a growing number of children.
Paulina Horvei +2 more
semanticscholar +1 more source
Changes in coagulation status in patients with β-thalassemia in Iraq: A case-control study
Medical Journal of Babylon, 2022 Background: The pathogenesis β-thalassemia is characterized by anemia resulting from reduced β-globin synthesis with low hemoglobin A (HbA) production and higher production of hemoglobin A2 (HbA2) and fetal hemoglobin (HbF).
Hussein Abdalzehra Wadaha +2 more
doaj +1 more source
Evaluation of Factors influencing the birth of Thalassemia in Family Members with Thalassemia Major in Southeast Iran in 2021 [PDF]
Journal of Advanced Biomedical Sciences, 2023 Background & Objectives: Beta-thalassemia is one of the complex diseases that causes many social and economic problems for the patient and his family. This study aimed to investigate factors influencing the birth of thalassemia (intermedia or major) in ...
Majid Naderi +5 more
doaj
A Hematologic Disease in the Turkish Republic of Northern Cyprus: Thalassemia Major
Mediterranean Nursing and Midwifery, 2023 Thalassemia is an inherited hematologic disease in which the body makes an abnormal form of hemoglobin. Patients are diagnosed with thalassemia major due to severe anemia and clinical symptoms.
Hazel Şahin Tarım, Fatma Öz
doaj +1 more source
Evaluation of the Association of Transferrin Receptor Type 2 Gene Mutation (Y250X) with Iron Overload in Major β-Thalassemia [PDF]
Archives of Razi Institute, 2021 Thalassemia is an inherited blood disorder in which the body produces defective hemoglobin. One of the important processes to reduce the complication of major β-thalassemia is blood transfusion that leads to elevated ferritin levels in the blood.
J Abdulmalek Jaafar, N. A. M Al-Rashedi
doaj +1 more source
Diabetes Care, 2020 OBJECTIVE We systematically explored the link of pancreatic iron with glucose metabolism and with cardiac complications in a cohort of 1,079 patients with thalassemia major (TM) enrolled in the Extension-Myocardial Iron Overload in Thalassemia (E-MIOT ...
A. Pepe +20 more
semanticscholar +1 more source
Effects of blood transfusion on exercise capacity in thalassemia major patients [PDF]
, 2015 Anemia has an important role in exercise performance. However, the direct link between rapid changes of hemoglobin and exercise performance is still unknown.To find out more on this topic, we studied 18 beta-thalassemia major patients free of relevant ...
Agostoni, P +8 more
core +6 more sources
Molecular Genetics & Genomic Medicine, 2020 Background Hepcidin and hemochromatosis (HFE) are iron regulatory proteins that are encoded by HAMP and HFE genes. Mutation in either HAMP gene or HFE gene causes Hepcidin protein deficiency that can lead to iron overload in beta thalassemia patients ...
Maryam Shah +7 more
doaj +1 more source
BMC Medical Genetics, 2020 Background β Thalassemia is one of the most common groups of hereditary haemoglobinopathies. Affected people with thalassemia major are dependent on regular blood transfusion which on the long term leads to iron overload.
Parinaz Zarghamian +4 more
semanticscholar +1 more source