Results 51 to 60 of about 5,420,950 (275)
Cardiac Complications in Thalassemia Major [PDF]
Hemoglobin, 2009 Thalassemia major is characterized by chronic ineffective erythropoiesis and anemia as its primary problems. These, in turn, produce physiologic adaptations in the cardiovascular system as well as pathologic/iatrogenic processes such as iron overload, splenectomy, nutritional deficiencies, chronic oxidative stress, and lung disease.
openaire +3 more sources
Developmental Dynamics, EarlyView.Abstract Disruption of extracellular pH and proton‐sensing can profoundly impact cellular and protein functions, leading to developmental defects. To visualize changes in extracellular pH in the developing embryo, we generated a zebrafish transgenic line that ubiquitously expresses the ratiometric pH‐sensitive fluorescent protein pHluorin2, tethered to
Leif R. Neitzel +5 more
wiley +1 more source
Premature atherosclerosis in children with beta-thalassemia major: New diagnostic marker
BMC Pediatrics, 2017 BackgroundEarly vascular alteration, atherosclerosis and coronary artery disease have emerged as important cardiovascular complications among beta-thalassemia major (B-TM) patients. The aims of the current study were to assess the prevalence of premature
L. Sherief +9 more
semanticscholar +1 more source
Current Progress in Targeting Human Cytomegalovirus Infection
iLABMED, EarlyView.This review highlights recent advances in the mechanisms by which human cytomegalovirus (HCMV) maintains its genome in infected cells, as well as the cellular factors and viral antigens that modulate viral reactivation, which reveal potential targets for addressing HCMV infection.
Yonggang Pei, Jun Chen
wiley +1 more source
New insights into applications of base editor in hereditary disorders
Interdisciplinary Medicine, EarlyView.Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai +8 more
wiley +1 more source
Brucella Sacroiliitis in Thalassemia Major [PDF]
The Indian Journal of Pediatrics, 2014 To the Editor: A 17-y-old boy was admitted with fever, right sided hip pain and limping since 2 mo. He had been under treatment for thalassemia major since the age of 1 y with regular RBC transfusion and iron chelation. Physical examination revealed fever and limitation of right hip movement.
Topal, Yasar +2 more
openaire +3 more sources
A comprehensive review on adaptive plasticity and recovery mechanisms post‐acquired brain injury
Neuroprotection, EarlyView.This figure illustrates the dynamic process of neurogenesis following brain injury, focusing on the roles of neural stem and progenitor cells at the injury site. Key mechanisms include axonal sprouting, synaptogenesis, dendritic remodeling, and brain‐derived neurotrophic factor signaling via TrkB receptors.
Ravi Kumar Rajan
wiley +1 more source
Evaluation of QT interval in β thalassemia major patients in comparison with control group
Heart Views, 2012 Background: Cardiac complications are the primary cause of death in patients with b thalassemia major. QTc interval is an indicator of variability of ventricular repolarization and is supposed to be prominent in high risk patients.
Behzad Farahani +3 more
doaj +1 more source
ChemistryOpen, EarlyView.The ethyl acetate extract of Curio radicans is found to contain a higher proportion of bioactive compounds (55% vs 30% in the ethanolic extract) by gas chromatography‐mass spectrometry, and it exhibits stronger antioxidant activity in the DPPH assay (75% vs 65% inhibition) as well as clear genoprotective effects against H2O2‐induced DNA damage ...
Muhammad Naseer +6 more
wiley +1 more source