Results 81 to 90 of about 5,420,950 (275)
Cell Proliferation, EarlyView.CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far +4 more
wiley +1 more source
The FEBS Journal, EarlyView.Under normoxic conditions, the SUMOylated fraction of TFAP2A cannot interact with the Ku70/Ku80 complex, nor it can bind to chromatin. The unSUMOylated fraction pre‐occupies the chromatin of a subset of hypoxia‐induced genes together with the Ku70/Ku80 complex for basal euchromatin formation. Under hypoxic conditions, the SUMOylation equilibrium shifts
Amalia Kanoura +8 more
wiley +1 more source
Molecular Testing in Sickle Cell Disease: From Newborn Screening to Transfusion Care
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Sickle cell disease (SCD) is one of the most frequent monogenic diseases worldwide and a highly heterogeneous and complex disease. SCD care carries several challenges. This includes early and accurate diagnosis as well as optimal red blood cell transfusion matching in this population carrying a high risk of alloimmunization.
Thomas Pincez, Yves D. Pastore
wiley +1 more source
Immune Response of Thalassemia Major Patients in Indonesia with and without Splenectomy
Acta Medica Indonesiana, 2016 Aim: to describe non-spesific and specific immune response profile in Indonesian thalassemia major with and without splenectomy. Methods: this study was held at Thalassaemia Centre, Cipto Mangunkusumo Hospital Jakarta on September 2013 – February 2014 ...
Teny T Sari1 +6 more
doaj +2 more sources
Economic burden of sickle cell disease in Australia
Internal Medicine Journal, EarlyView.Abstract Background Sickle cell disease (SCD) is an inherited condition that impairs red blood cell function, posing a substantial health burden on patients. As the prevalence of SCD in Australia rises due to migration, discussions surrounding treatment and management strategies are becoming more prominent. Aims Australia lacks a dedicated study on the
Steve Nwokeocha +16 more
wiley +1 more source
Health Psychology Open, 2017 The present research analyzed the elements of thalassemia which affect the patient’s perceived quality of life. Three hundred patients with Thalassemia Major (males = 165, 55%; females = 135, 45%; Mage = 36.13, standard deviation = 8.54) were the sample.
Silvia Platania +4 more
semanticscholar +1 more source
B- THALASSEMIA MAJOR IN RAMADI
مجلة كلية الطب, 2005 Background:
Zeina H Al Shemmari +2 more
doaj +1 more source
International Journal of Paediatric Dentistry, EarlyView.ABSTRACT Background Molar incisor hypomineralization (MIH) is associated with enamel's existing qualitative developmental defects. Aim This study aimed to assess the cortical and trabecular mandibular bone morphology in pediatric patients with MIH using fractal analysis (FA) and digital panoramic radiography (DPR) with various radiomorphometric indices.
Asli Soğukpinar Önsüren +1 more
wiley +1 more source
Nutrition Bulletin, EarlyView.ABSTRACT Pregnancy is a crucial period during which maternal nutrition, weight and lifestyle behaviours have a direct impact on both maternal and fetal health. This briefing paper describes dietary and lifestyle recommendations for women during the preconceptional period and throughout pregnancy, identifying specific factors that can be modified to ...
Kathryn H. Hart +5 more
wiley +1 more source