Results 91 to 100 of about 4,949,451 (244)

Increase in fetal haemoglobin from baseline to day 10 is a biomarker for response to decitabine in AML: Results of the AML21 randomized phase III trial of the EORTC Leukemia Group, Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) and German MDS Study Group

British Journal of Haematology, EarlyView.
Summary Lack of response or delayed response to therapy are major challenges in the use of DNA‐hypomethylating agents (HMA) in patients with acute myeloid leukaemia (AML). Fetal haemoglobin (HbF) is a potential biomarker for response to HMA treatment but has only been studied in small single‐centre studies.
Julia Stomper, Michal Kicinski, Tobias Ma, Thomas Meyer, Sylvain Chantepie, Richard Noppeney, Mario Luppi, Ernesta Audisio, Laimonas Griškevičius, Andreas Neubauer, Robin Foà, Walter J. F. M. Van der Velden, Anna Candoni, Radovan Vrhovac, Gianluca Gaidano, Catharina Van Elssen, Mels Hoogendoorn, Maurizio Musso, Attilio Olivieri, Christian Junghanß, Emmanuel Bissé, Stephanie Antunes, Frédéric Baron, Adriano Venditti, Joop H. Jansen, Pierre W. Wijermans, Gerwin Huls, Michael Lübbert   +27 more
wiley   +1 more source

Vacuolated white blood cells in thalassemia major

, 1994
We report a case of thalassemia major in which severe cytoplasmic vacuolization was seen in white blood cells as well as in their precursors. Cytochemical examination of the vacuoles revealed Sudan Black staining.
Fatma Gümrük, Aytemiz Gürgey, Feride Duru   +2 more
core   +1 more source

The Correlation of ?/? mRNA Ratio with Clinical and Hematological Parameters in Patients with ?-thalassemia Syndrome

The Iraqi Journal of Medical Sciences, 2022
Background: Thalassemias are a group of genetically transmitted blood diseases characterized by defects in the production of ?- or ?-chains of hemoglobin called ?-thalassemia and ?-thalassemia, respectively.
May H. Yousif, Hind S. Al-Mamoori
doaj   +2 more sources

Beta Thalassemia Major Bone Marrow Transplant [PDF]

Bone Marrow Transplant is the only possible cure till now for the genetic disorder thalassemia. Thalassemia Major can be managed by regular blood transfusions and iron chelation, but the quality of life is still poor and individuals suffering from this ...
Anand, Ayush
core   +1 more source

Copper Status in Patients with Thalassemia Major in Zahedan, Iran

International Journal of Hematology-Oncology and Stem Cell Research, 2013
Introduction: There have been many reports and papers on deficient, normal and high levels of copper in patients with thalassemia major. The aim of this study is to evaluate copper status in a series of more than 300 patients with thalassemia major and ...
Mohamad Ali Mashhadi
doaj  

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Smartphone‐Based Teledentistry to Support Clinical Triage and Risk‐Informed Dental Care in Patients With Inherited Bleeding and Haemoglobin Disorders: A Cross‐Sectional Diagnostic Agreement Study

Haemophilia, EarlyView.
ABSTRACT Introduction Patients with inherited bleeding and haemoglobin disorders face barriers to accessing timely dental care, increasing the risk of untreated oral disease and complications related to invasive procedures. Aim To evaluate the agreement between smartphone‐based asynchronous teledentistry and face‐to‐face examination for oral conditions,
Victor Cordeiro da Silva, Carolina Mendes Frusca do Monte, Leandro Tavares da Silva, Gabriela Silva Almeida, Claudia Santos Lorenzato, José Vitor Nogara Borges de Menezes, Fabian Calixto Fraiz, Cassius Carvalho Torres‐Pereira   +7 more
wiley   +1 more source

Changes in the quality of life of people with thalassemia major between 2001 and 2009

, 2013
Giorgia Gollo,1 Gaia Savioli,2 Manuela Balocco,2 Cristina Venturino,3 Elio Boeri,4 Massimo Costantini,1 Gian Luca Forni21Regional Palliative Care Network, IRCCS AOU San Martino-IST, Genoa; 2Hematology, Center for Thalassemia, Galliera Hospital, Genoa ...
Venturino C, Costantini M, Gollo G, Balocco M, Boeri E, Forni GL, Savioli G   +6 more
core  

HYPOTHYROIDISM INCIDENCE IN PATIENTS OF Β THALASSEMIA MAJOR

, 2022
Objective: This research's primary objective was to classify the occurrence of hypothyroidism in patients with major β-thalassemia. Place and duration of study: This research was performed from July 2020 to February 2021 in the Pediatrics Department of ...
Dr Assad ullah, Dr Usaid, Dr Rimsha Rameen
core   +1 more source

Differentiating β‐Thalassaemia From Iron Deficiency: Performance and Cut‐Off Dependency of More Than 40 Red Cell Discrimination Indices in a Large German Cohort

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Since the 1970s, more than 40 red blood cell–based formulas have been proposed to differentiate β‐thalassaemia trait (BTT) from iron deficiency (ID) and iron deficiency anaemia (IDA), the main causes of microcytic anaemia. In Germany, where haemoglobinopathies are rare in the autochthonous population but increasingly encountered due
Rafid Al‐Nabhan, Dani Hakimeh, Lena Oevermann   +2 more
wiley   +1 more source