Results 111 to 120 of about 4,949,451 (244)
Hypogonadism in thalassemia major patients
Journal of Clinical & Translational Endocrinology, 2016 Despite recent advances in iron chelation therapy, excess iron deposition in pituitary gonadotropic cells remains one of the major problems in thalassemic patients. Hypogonadism, mostly hypogonadotropic hypogonadism, is usually detected during puberty.
Sasima Srisukh +2 more
openaire +3 more sources
The Journal of Physiology, EarlyView.Abstract figure legend Downregulation of mitotically associated long non‐coding RNA (MANCR) disturbs transcriptome and proteome in endothelial cells, possibly leading to endothelial and vascular dysfunction in preeclampsia. Abstract Preeclampsia (PE) is a hypertensive disorder during pregnancy, which is characterized by a wide spectrum of endothelial ...
Si‐Yan Zhang, Chi Zhou, Jing Zheng
wiley +1 more source
PSYCHOSOCIAL FACTORS ASSOCIATED WITH MAJOR THALASSEMIA [PDF]
Thalassemia is a hereditary condition that results in the creation of defective haemoglobin molecules. Patients are diagnosed with thalassemia major after exhibiting severe clinical symptoms and profound anaemia.
Al_Hamadiny, Shahad Qasim +5 more
core +2 more sources
American Journal of Hematology, Volume 101, Issue 12, Page 2961-2975, December 2026.ABSTRACT Although circulating nucleated red blood cells (cNRBCs) have previously been detected in patients with sickle cell disease (SCD), their prevalence and clinical significance during steady‐state disease have not been established. We retrospectively analyzed 270 adults with an SS or Sβ0‐thalassemia genotype.
Ugo Boccadifuoco +7 more
wiley +1 more source
To assess the roles of genetic modifiers in Iraqi β-thalassemia patients, and determine whether a genotype-based scoring system could be used to predict phenotype, a total of 224 Iraqi patients with molecularly characterized homozygous or compound ...
Regir K Sadullah (18015372) +8 more
core +1 more source
, 2018 Objective and importance: To verify the presence of β-thalassemia in subjects showing hematologic phenotype of α-thalassemia, conduct normal molecular sequence analysis of the α-globin genes, and detect the absence of the most frequent α-thalassemia ...
Clelia Scarano (2879918) +5 more
core +1 more source
Impact of Heat Block Drying on Morphologic Preservation and Staining of Peripheral Blood Smears
International Journal of Laboratory Hematology, Volume 48, Issue 6, Page 1341-1347, December 2026.ABSTRACT Introduction Morphologic evaluation of the peripheral blood smear is critical for diagnosis and ruling out certain hematologic disorders. While air‐drying is standard, some laboratories may use heat blocks to expedite drying. Excessive heat may induce morphologic artifacts, but there is a lack of systematic literature on this practice ...
Ryan C. Shean +4 more
wiley +1 more source
American Journal of Hematology, Volume 101, Issue 11, Page 2799-2811, November 2026.ABSTRACT Children with SCD have elevated stroke risk, correlated with cerebral blood flow velocity (CBFV). HOPE Kids 2 was a phase 3, multicenter, double‐blind, placebo‐controlled trial evaluating the effect of voxelotor on CBFV. Participants aged 2 to < 15 years with SCD (HbSS/HbSβ0) and conditional CBFV (170 to < 200 cm/s) were randomized 1:1 to ...
Halima Bello‐Manga +58 more
wiley +1 more source
Immune Response of Thalassemia Major Patients in Indonesia with and without Splenectomy
Acta Medica Indonesiana, 2016 Aim: to describe non-spesific and specific immune response profile in Indonesian thalassemia major with and without splenectomy. Methods: this study was held at Thalassaemia Centre, Cipto Mangunkusumo Hospital Jakarta on September 2013 – February 2014 ...
Teny T Sari1 +6 more
doaj +2 more sources
Does Molecularly Guided Therapy Change the Surgical Goals of Glioma Resection?
Brain and Behavior, Volume 16, Issue 11, November 2026.ABSTRACT Purpose For more than 20 years, the goal of glioma surgery has been to remove as much tumor as possible without compromising patient safety. Many retrospective studies support that greater extent of resection is often associated with longer survival. However, three recent developments have challenged this traditional approach.
Naeem Ul Haq +8 more
wiley +1 more source