Results 101 to 110 of about 1,355,299 (308)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The Preventive Check in Medieval and Pre-industrial England [PDF]
England’s post-Reformation demographic regime has been characterized as ‘low pressure’. Yet the evidence hitherto for the presence of a preventive check, defined as the short-run response of marriage and births to variations in living standards, is ...
Cormac Ó Gráda, Morgan Kelly
core
The research carried out in 2009 in the multicultural site Gnidavs'ka Gìrka near Łuck [PDF]
, 2010 У статті проаналізовано результати досліджень на багатошаровому поселенні Гнідавська Гірка с.Рованці: на площі 636,5 кв.м. виявлено і досліджено 50 археологічних об'єктів від епохи неоліту до пізнього середньовіччяThe article presents the effects of the ...
Bardetskyi, Andrii +3 more
core
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Cost Accounting in Early Regulated Markets: The Case of the Royal Soap Factory of Seville, 1525-1692 [PDF]
(WP 16/03 Clave pdf) Regulated markets and state-owned monopolies characterized the economies of many Southern European territories around the end of the Middle Ages and during the Renaissance.
SALVADOR CARMONA
core
Up-to-date Spanish continental Neogene synthesis and paleoclimatic interpretation [PDF]
, 1992 A synthesis of the Spanish continental Neogene is presented by designing an integrated correlative chart of the Neoc "gen-e -succes-siuns-ofthe -lberian-PeninsuIa-.-Ninemain-sedimentary-breaks-have-been-distinguished-in-most-of-the-basins~ -'I'hey are ...
Torres Pérez-Hidalgo, Trinidad José
core +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Different Approach to Horses-The Use of Equid Remains in the Early Middle Ages on the Example of Ostrów Tumski in Wroclaw. [PDF]
Animals (Basel), 2020 Jaworski K +3 more
europepmc +1 more source