Results 121 to 130 of about 1,355,299 (308)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Archaeological research into the periods following the Early Middle Ages in Slovenia

Arheološki Vestnik, 2010
The  authors  outline  the  archaeological  research  into the  periods  following  the  Early  Middle  Ages  in  Slovenia, from  its  beginnings  in  the  late  19th  centur y  up  to  the present.
Katarina Predovnik, Tomaž Nabergoj
doaj  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Architecture of Lovran in the late Middle Ages and early modern period

Zbornik Lovranšćine, 2010
Based on the review of existing studies on urbanism and architecture of Lovran, on meticulous field work and analysis of both published and unpublished graphic sources, new observations on the architecture of the old town of Lovran, its settlement and ...
Marijan Bradanović
doaj  

Biostratigraphie par Acritarches du Cambro-Ordovicien de Belgique et des regions limitotrophes: synthese et perspectives d'avenir [PDF]

, 1992
The stratigraphic significance of Cambrian and Ordovician acritarchs in Belgium and adjacent areas is discussed. It now appears that the age of the Deville group in the Ardenne (more precisely the upper part of this group) should be broadened to include ...
Vanguestaine, M.
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Two in one: the use of "deer" stone for making a statue in the Turkic period (results of photogrammetry in the archaeological and architectural complex "Burana Tower" in Kyrgyzstan)

Поволжская археология
"Deer" stones on the territory of Kyrgyzstan are rare finds. This situation is due to several reasons. Special and systematic identification of such ancient statues has not yet been undertaken.
Tishkin Alexey A. , Tabaldiev Kubatbek Sh., Bondarenko Sergey Y.   +2 more
doaj   +1 more source

7. Jerusalem: St. Augustine

, 1958
Perhaps no individual after Paul exercised an influence on t he history of Christianity comparable to that of Augustine (354- 430). Beyond a doubt the greatest of the Latin Church fathers, he lived during the years when the formative period of the ...
Bloom, Robert L., Crapster, Basil L., Dunkelberger, Harold A., Glatfelter, Charles H., Mara, Richard T., Richardson, Norman E., Schubart, W. Richard   +6 more
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source