Results 81 to 90 of about 266,495 (261)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Archaeological research into the periods following the Early Middle Ages in Slovenia

Arheološki Vestnik, 2010
The  authors  outline  the  archaeological  research  into the  periods  following  the  Early  Middle  Ages  in  Slovenia, from  its  beginnings  in  the  late  19th  centur y  up  to  the present.
Katarina Predovnik, Tomaž Nabergoj
doaj  

CULTURAL AND INTELLECTUAL SPACE OF THE EARLY MIDDLE AGES: THE PHENOMENON OF BOETHIUS

Епістемологічні дослідження у філософії, соціальних і політичних науках
The specificity of the cultural and intellectual space of the early Middle Ages is explored through the prism of the activity of Anicius Manlius Severinus Boethius. The phenomenon of Boethius individuality and creativity is viewed as the primary element
Вікторія ВЕРШИНА
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Findings of Ritual Spoons of the Early Middle Ages in the Oka-Sviyaga Interfluve

Поволжская археология, 2016
The article discusses medieval ritual spoons found on the territory between the Oka and Sviyaga rivers, so far quite poorly studied. These fi nds, especially in the context of funerary complexes, supplement our knowledge of the pagan cults practiced by ...
Grishakov Valeriy V., Sedishev Oleg V., Lyubimkina Elena S.   +2 more
doaj   +2 more sources

Architecture of Lovran in the late Middle Ages and early modern period

Zbornik Lovranšćine, 2010
Based on the review of existing studies on urbanism and architecture of Lovran, on meticulous field work and analysis of both published and unpublished graphic sources, new observations on the architecture of the old town of Lovran, its settlement and ...
Marijan Bradanović
doaj  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Two in one: the use of "deer" stone for making a statue in the Turkic period (results of photogrammetry in the archaeological and architectural complex "Burana Tower" in Kyrgyzstan)

Поволжская археология
"Deer" stones on the territory of Kyrgyzstan are rare finds. This situation is due to several reasons. Special and systematic identification of such ancient statues has not yet been undertaken.
Tishkin Alexey A. , Tabaldiev Kubatbek Sh., Bondarenko Sergey Y.   +2 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source