Results 81 to 90 of about 1,240,679 (194)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Apropierea și întârzierea parousiei la părinții ante- și post-niceeni – partea a II-a
TheoRhēma, 2016 The concepts of the nearness and delay of parusia in the thought of the ante- and post-Nicene Fathers, dealt with in part one, have here been taken up again, this time with a focus on the way the Nicene and post-Nicene Fathers related to the nearness ...
Laurențiu Moț
doaj +2 more sources
Polis: Revista de Stiinte Politice, 2014 Although some of the authors of the relevant literature believe that the phrase “cultural imperialism” is a subtle, “soft” form of domination, which does not involve an open, visible or military political control (in realistic terms), other scholars ...
Mădălina Virginia ANTONESCU
doaj
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
TheoRhēma, 2016 he concepts of the nearness and delay of parusia in the thought of the ante- and post-Nicene Fathers, dealt with in part one, have here been taken up again, this time with a focus on the way the Nicene and post-Nicene Fathers related to the nearness and
Laurențiu Moț
doaj
Coronavirus at the end of the world: Antarctica matters. [PDF]
Soc Sci Humanit Open, 2020 Frame B, Hemmings AD.
europepmc +1 more source
Uncovering the species diversity of subterranean rodents at the end of the World: three new species of Patagonian tuco-tucos (Rodentia, Hystricomorpha, Ctenomys). [PDF]
PeerJ, 2020 Teta P, D'Elía G.
europepmc +1 more source
From Books to the Silver Screen: Transformations of Michael Cunningham’s Fiction
American and British Studies Annual, 2008 By 1999 when Michael Cunningham published The Hours not many people had known his name although he had already written two other novels. The success of The Hours followed by a movie of same name made Cunningham world-wide known.
Ivan Burda
doaj