Results 101 to 110 of about 128,360,030 (297)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A Data-driven Approach for Estimating the Fundamental Diagram
Promet (Zagreb), 2019 The fundamental diagram links average speed to density or traffic flow. An analytic form of this diagram, with its comprehensive and predictive power, is required in a number of problems. This paper argues, however, that, in some assessment studies, such
Neila Bhouri +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Weakly coupled conformal gauge theories on the lattice
EPJ Web of Conferences, 2018 Results are reported for the β-function of weakly coupled conformal gauge theories on the lattice, SU(3) with Nf = 14 fundamental and Nf = 3 sextet fermions.
Fodor Zoltan +4 more
doaj +1 more source
Electroweak baryogenesis from temperature-varying couplings
Journal of High Energy Physics, 2019 The fundamental couplings of the Standard Model are known to vary as a function of energy scale through the Renormalisation Group (RG), and have been measured at the electroweak scale at colliders. However, the variation of the couplings as a function of
Sebastian A. R. Ellis +2 more
doaj +1 more source
COUNTING RATIONAL POINTS ON HYPERSURFACES AND HIGHER ORDER EXPANSIONS [PDF]
, 2016 a
Fundamental mathematics +3 more
core +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Fundamental diagram of traffic flows on urban roads – local versus whole-link approaches [PDF]
, 2009 Fundamental diagrams of traffic flow variables have been quite useful in determining freeway operations quality. However, they are usually not used for that purpose on urban roads.
Elmar Brockfeld +8 more
core +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source