Results 61 to 70 of about 980,468 (308)

Structural Volatility Impulse Response Analysis

Journal of Financial Econometrics
Abstract We make three contributions to the volatility impulse response function (VIRF) developed by Hafner and Herwartz (2006). First, we derive its law for multivariate GARCH models of the BEKK type. Second, we present a structural embedding of the VIRF, leveraging recent advancements in the identification of multivariate generalized ...
Matthias R Fengler, Jeannine Polivka
openaire   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Impulse Response Confidence Intervals for Persistent Data: What Have We Learned? [PDF]

This paper is a comprehensive comparison of existing methods for constructing confidence bands for univariate impulse response functions in the presence of high persistence.
Elena Pesavento, Barbara Rossi
core   +2 more sources

Transient Dynamic Analysis of a Cantilever Rod with Axial Impulse Loading Using Finite Element Method

MATEC Web of Conferences, 2018
The behavior of bodies subjected to impulse loading is of prime importance in the study of forces that occur in impulse facilities. Before performing the actual tests, theoretical and numerical simulations are carried out to obtain the response of bodies
Deka Sushmita, Ramesh Babu Pallekonda, Rahang Maneswar   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The market impact of a limit order [PDF]

, 2009
Despite their importance in modern electronic trading, virtually no systematic empirical evidence on the market impact of incoming orders is existing.
Hautsch, Nikolaus, Ruihong Huang, Nikolaus Hautsch, Huang, Ruihong   +3 more
core   +1 more source

Extended Use for the Frequency Response Analysis: Switching Impulse Voltage Based Preliminary Diagnosis of Potential Sources of Partial Discharges in Transformer

Applied Sciences, 2020
The Frequency Response Analysis approach (FRA) is useful in the fault diagnosis of transformers. However, its usefulness in diagnosing any potential sources of Partial Discharge (PD) in transformers has not been thoroughly investigated so far.
Kamalaselvan Arunachalam, Balasubramanian Madanmohan, Rajesh Rajamani, Natarajan Prabaharan, Hassan Haes Alhelou, Pierluigi Siano   +5 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Model-Free Impulse Responses [PDF]

This paper introduces methods for computing impulse response functions that do not require specification and estimation of the unknown dynamic multivariate system itself.
Oscar Jorda
core   +2 more sources