Results 91 to 100 of about 127,858,707 (311)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Low-power differencing feature extracts spiking-band activities for high-performance intracortical brain-computer interfaces

Communications Biology
Intracortical brain-computer interfaces (iBCIs) demand computationally efficient feature extraction methods to process high-bandwidth neural signals in resource-constrained implantable systems.
Guangxiang Xu, Chenbin Yu, Gengrong Shao, Gang Pan, Yueming Wang, Yaoyao Hao   +5 more
doaj   +1 more source

Double emulsions of full-active sunscreen ingredients for enhanced broad-spectrum UV protection [PDF]

RSC Applied Interfaces
Multiple emulsions enable the advanced encapsulation of active ingredients, making them favorable in cosmetic formulations. In this study, natural protein casein is employed to facilitate the ultrasound-assisted encapsulation of emollient-free, full ...
Kanaparedu P. C. Sekhar, Caiyun Shan, Ruizheng Zhang, Mengran Jiao, Jingcheng Hao, Aixin Song, Jiwei Cui   +6 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Improved Electrochemical Performance of LiMn2O4/Graphene Composite as Cathode Material for Lithium Ion Battery

International Journal of Electrochemical Science, 2012
The electrochemical performance especially rate capability of LiMn2O4 is improved by graphene modified via ultrasonic agitation. The pristine LiMn2O4 and LiMn2O4/graphene composite are characterized by X-ray diffraction (XRD) and transmission electron ...
Huayun Xu, Bin Cheng, Yunpo Wang, Long Zheng, Xinhui Duan, Lihui Wang, Jian Yang, Yitai Qian   +7 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Bone–titanium oxide interface in humans revealed by transmission electron microscopy and electron tomography

, 2011
Osseointegration, the direct contact between an implant surface and bone tissue, plays a critical role in interfacial stability and implant success.
Palmquist, Anders,, Peter Thomsen, Norlindh, Birgitta,, Torsten Mattsson, Rickard Brånemark, Kathryn Grandfield, Grandfield, Kathryn,, Grandfield, Kathryn, Anders Palmquist, Thomsen, Peter,, Birgitta Norlindh, Mattson, Torsten,, Brånemark, Rickard,, Mattsson, Torsten   +13 more
core   +1 more source

Product–process interface for manufacturing data management as a support for DFM and virtual manufacturing [PDF]

, 2008
This research work was supported by SNECMA as part of the MAIA ( http://www.le-webmag.com/article.php3?id_ article=2&lang=) project, the Region Champagne-Ardennes and Sisson Lehmann of the Wheelabrator group.In order to tackle a continuous improvement of
Jawhar Elgueder, Lionel Roucoules, El Gueder, Jawhar, ROUCOULES, Lionel, COCHENNEC, Florent, ROUHAUD, Emmanuelle, Florent Cochennec, Emmanuelle Rouhaud, ELGUEDER, Jawhar   +8 more
core   +1 more source

AR-13, a Celecoxib Derivative, Directly Kills Francisella In Vitro and Aids Clearance and Mouse Survival In Vivo

Frontiers in Microbiology, 2017
Francisella tularensis (F. tularensis) is the causative agent of tularemia and is classified as a Tier 1 select agent. No licensed vaccine is currently available in the United States and treatment of tularemia is confined to few antibiotics.
Ky V. Hoang, Haley E. Adcox, James R. Fitch, David M. Gordon, Heather M. Curry, Larry S. Schlesinger, Peter White, Peter White, John S. Gunn   +8 more
doaj   +1 more source