Results 91 to 100 of about 1,794,418 (319)

Phosphorylation at the Interface [PDF]

Structure, 2011
Proteomic studies have identified thousands of eukaryotic phosphorylation sites (phosphosites), but few are functionally characterized. Nishi et al., in this issue of Structure, characterize phosphosites at protein-protein interfaces and estimate the effect of their phosphorylation on interaction affinity, by combining proteomics data with protein ...
openaire   +2 more sources

Characterization and modelling of moisture driven interface failures

, 2004
Since moisture sensitivity level (MSL) tests are part ofthe international reliability qualification standards, all the microelectronics components/products have to pass these specifications.
Driel, WD Willem van, van Driel, W.D., Schreurs, PJG Piet, Habets, P.J.J.H.A., Zhang, G.Q., Gils, van, M.A.J., Gils, MAJ Marcel van, Schreurs, P.J.G., Habets, PJJHA, Zhang, GQ Kouchi   +9 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Bone–titanium oxide interface in humans revealed by transmission electron microscopy and electron tomography

, 2011
Osseointegration, the direct contact between an implant surface and bone tissue, plays a critical role in interfacial stability and implant success.
Palmquist, Anders,, Peter Thomsen, Norlindh, Birgitta,, Torsten Mattsson, Rickard Brånemark, Kathryn Grandfield, Grandfield, Kathryn,, Grandfield, Kathryn, Anders Palmquist, Thomsen, Peter,, Birgitta Norlindh, Mattson, Torsten,, Brånemark, Rickard,, Mattsson, Torsten   +13 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Improved Electrochemical Performance of LiMn2O4/Graphene Composite as Cathode Material for Lithium Ion Battery

International Journal of Electrochemical Science, 2012
The electrochemical performance especially rate capability of LiMn2O4 is improved by graphene modified via ultrasonic agitation. The pristine LiMn2O4 and LiMn2O4/graphene composite are characterized by X-ray diffraction (XRD) and transmission electron ...
Huayun Xu, Bin Cheng, Yunpo Wang, Long Zheng, Xinhui Duan, Lihui Wang, Jian Yang, Yitai Qian   +7 more
doaj   +1 more source

Interfacial dynamics in diffusion-driven phase transformations [PDF]

, 1990
The migration of ledges in a semicoherent a/ß interface is considered to participate in solid-state transformations driven by diffusion. The advance of the ledge and/or the progress of the transformation can require the climb of misfit dislocations both ...
Loo, FJJ Frans van, Rapp, R.A., Loo, van, F.J.J., B. P Ieraggi, F. J. J. Van Loo, Pieraggi, B, Rapp, RA, J. P. H Irth, Pieraggi, B., R. A. Rapp, Hirth, J.P., Hirth, JP   +11 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

AR-13, a Celecoxib Derivative, Directly Kills Francisella In Vitro and Aids Clearance and Mouse Survival In Vivo

Frontiers in Microbiology, 2017
Francisella tularensis (F. tularensis) is the causative agent of tularemia and is classified as a Tier 1 select agent. No licensed vaccine is currently available in the United States and treatment of tularemia is confined to few antibiotics.
Ky V. Hoang, Haley E. Adcox, James R. Fitch, David M. Gordon, Heather M. Curry, Larry S. Schlesinger, Peter White, Peter White, John S. Gunn   +8 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source