Results 81 to 90 of about 4,294,020 (272)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Frontiers in Microbiology, 2017 Francisella tularensis (F. tularensis) is the causative agent of tularemia and is classified as a Tier 1 select agent. No licensed vaccine is currently available in the United States and treatment of tularemia is confined to few antibiotics.
Ky V. Hoang +8 more
doaj +1 more source
, 2016 Minimal models of self-propelled particles with short-range volume exclusion interactions have been shown to exhibit signatures of phase separation.
Lee, Chiu Fan
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
The Rational Design and Biological Mechanisms of Nanoradiosensitizers
Nanomaterials, 2020 Radiotherapy (RT) has been widely used for cancer treatment. However, the intrinsic drawbacks of RT, such as radiotoxicity in normal tissues and tumor radioresistance, promoted the development of radiosensitizers.
Hainan Sun, Xiaoling Wang, Shumei Zhai
doaj +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
International Journal of Electrochemical Science, 2012 Porous LiAlxMn2-xO4 (x=0, 0.05, 0.1, 0.15) nanoparticles were synthesized by sol-gel method. Differential scanning calorimetry and thermogravimetric analysis (DSC/TGA) were applied to determine the phase transition temperature and the decomposition ...
Huayun Xu +5 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Noninvasive monitoring of changes in intracranial fluid and tissue composition
Biomedical Engineering AdvancesContinuous assessment of changes in the fluid and tissue composition of the brain, as they occur with certain space-occupying disorders, is currently not possible.
Andrea Boraschi +2 more
doaj +1 more source
An interface element based on the partition of unity [PDF]
, 2001 An alternative interface finite element is developed. By using the partition of unity property of finite element shape functions, discontinuous shape functions are added to the standard finite element basis.
Remmers, JJC, Simone, A, Wells, GN
core