Results 121 to 130 of about 629,141 (310)
Meaning in Life, a Meaningful Life, and the Meaning of Life
, 2022 The present study concerns the general topic of life’s meaning or the meaning of life. There are three facets which I examine under this broad heading: meaning in life, meaningfulness/a meaningful life, and the meaning of life (understood in a more ...
Chang, Joshua
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Appearance of Superhuman in the Sky of Nietzscheâs Thought [PDF]
Metaphysics, 2013 This paper aims at introducing characteristics of Nietzscheâs âSuperhumanâ as much as possible. Being principal subject in his philosophical activity, âSuperhumanâ is one of the most basic philosophical thoughts of Nietzsche.
A Emami, H Alavitabar
doaj
How Meaning in Life Affects Goal Achievement
, 2019 Previous research has found meaning in life (i.e., a sense of life purpose; MIL) relates to many adaptive benefits such as increased mood, motivation, and goal achievement.
White, Grace
core
Gratitude and life satisfaction among Filipino adolescents: The mediating role of meaning in life
, 2015 The current research assesses the mediating effects of meaning in life on the relationship between gratitude and life satisfaction. A sample of Filipino college students (N = 409) in a private sectarian university completed the Gratitude Questionnaire ...
Mateo, Nino Jose +2 more
core +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Psychology Research and Behavior Management, 2020 Alessandra Costanza,1,2 Andrea Amerio,3– 5 Andrea Aguglia,3,4 Gianluca Serafini,3,4 Mario Amore3,4 1Department of Psychiatry, Faculty of Medicine, University of Geneva (UNIGE), Geneva, Switzerland; 2Department of Psychiatry, ASO Santi Antonio e ...
Costanza A +4 more
doaj
Meaning in Life as a Source of Entertainment
, 2013 In this paper we mean to introduce into the field of entertainment computing an overview of insights concerning fundamental human needs. Researchers such as Hassenzahl and Desmet, discuss design approaches based on psychological insights from various and varied sources.
Robby van Delden, Dennis Reidsma
openaire +1 more source