Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Realization of Values: Stages of Meaningful Living for Hafiz Quran Students
Psikis: Jurnal Psikologi IslamiThis study aimed to analyze the journey of finding meaning in life, focusing on the transformation from students’ meaningless inner feelings into meaningful feelings. This research is a field study with qualitative and phenomenological approaches.
Nayla Afna Sa’adah Nasution +2 more
doaj +1 more source
The Relationship Between the Meaning of Life, Psychological Well-Being, Self-Care, and Social Capital, with Depression and Death Anxiety in the Elderly Living in Nursing Homes: The Mediating Role of Loneliness [PDF]
, 2022 Majid Yousefi Afrashteh +3 more
openalex +1 more source
KORELASI ANTARA KEMAMPUAN HUBUNGAN INTERPERSONAL DENGAN KEBERMAKNAAN HIDUP PADA SARJANA YANG BELUM BEKERJA [PDF]
, 2009 Every human want to be prestige and useful for theirself, family and God. Every people hunger as someone who responsible and able to determine what to do and what can be better choice for theirself and social life. Every people wish to make interpersonal
WIJAYA, DHODIK
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
The Role of Psychiatric Symptoms, Social Support and Meaning in Life in Predicting Internet Addiction Among University Students: A Causal Model [PDF]
, 2018 Mohammad Ghaderi Rammazi +3 more
openalex +1 more source