Results 151 to 160 of about 32,046 (262)

Strong Chemical Tagging in the Milky Way

, 2020
Comprehending the evolutionary history of the Milky Way can offer great insight into how both our home Galaxy and others form and grow. However, studying the Milky Way from our position embedded within it is difficult, and this challenge is exacerbated ...
Price-Jones, Natalie Ruth
core  

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

When the Milky Way hosted a quasar

, 2022
Marin F, Churazov E, Khabibullin I, Ferrazzoli R, Gesu LD, Barnouin T, Marco AD, Middei R, Vikhlinin A, Costa E, Soffitta P, Muleri F, Sunyaev R, Forman W, Kraft R, Bianchi S, Donnarumma I, Petrucci P, Enoto T, Agudo I, Antonelli L, Bachetti M, Baldini L, Baumgartner W, Bellazzini R, Bongiorno S, Bonino R, Brez A, Bucciantini N, Capitanio F, Castellano S, Cavazzuti E, Chen C, Ciprini S, De Rosa A, Monte ED, Lalla ND, Doroshenko V, Dovciak M, Ehlert S, Evangelista Y, Fabiani S, Garcia J, Gunji S, Hayashida K, Heyl J, Ingram A, Iwakiri W, Jorstad S, Kaaret P, Karas V, Kitaguchi T, Kolodziejczak J, Krawczynski H, Monaca FL, Latronico L, Liodakis I, Maldera S, Manfreda A, Marinucci A, Marscher A, Marshall H, Massaro F, Matt G, Mitsuishi I, Mizuno T, Negro M, Ng C, O'Dell S, Omodei N, Oppedisano C, Papitto A, Pavlov G, Peirson A, Perri M, Pesce-Rollins M, Pilia M, Possenti A, Poutanen J, Puccetti S, Ramsey B, Rankin J, Ratheesh A, Roberts O, Romani R, Sgro C, Slane P, Spandre G, Swartz D, Tamagawa T, Tavecchio F, Taverna R, Tawara Y, Tennant A, Thomas N, Tombesi F, Trois A, Tsygankov S, Turolla R, Vink J, Weisskopf M, Wu K, Xie F, Zane S.   +103 more
europepmc   +1 more source

The Milky Way Galaxy

, 2009
This website provides a tutorial for students about the bulge, disk, and halo components of the Milky Way. It also contains information about the size and the formation of our galaxy.

core  

Electroacupuncture Improves the Learning and Memory by Modulating Hippocampal Glucose Metabolism through IGF1/IGF1R Signaling in Alzheimer's Disease

Advanced Science, EarlyView.
Electroacupuncture (EA) ameliorates learning and memory function in 5×FAD mice by regulating the brain glucose metabolic network. This neuroprotective effect is closely related to enhancing neuronal energy utilization via the IGF1/IGF1R signaling pathway.
Shengxiang Liang, Qingqing Zhang, Xiuxiu Wang, Lixin Peng, Xinru Ji, Jiawei Wang, Yusi Zhang, Jiayang Huang, Junchao Yang, Shiqi Zhan, Yiping Xiao, Weilin Liu, Lidian Chen   +12 more
wiley   +1 more source

Discovery of a high-velocity cloud of the Milky Way as a potential dark galaxy. [PDF]

Sci Adv
Liu XL, Xu JL, Jiang P, Zhu M, Zhang CP, Yu N, Xu Y, Guan X, Wang JJ.   +8 more
europepmc   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Chemodynamical evolution of the Milky Way

, 2003
We simulate the chemodynamical evolution of the Milky Way using our GRAPE-SPH code, and reproduce the age-metallicity relation, the [O/Fe]-[Fe/H] relation, and the metallicity ...
Nomoto, K., Nakasato, N., Kobayashi, C.
core  

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source