Results 141 to 150 of about 146,005 (284)

A Blueprint for the Milky Way’s Stellar Populations. V. 3D Local Dust Extinction

The Astrophysical Journal Supplement Series
Using a grid of empirically calibrated synthetic spectra developed in our previous study, we construct an all-sky 3D extinction map from the large collection of low-resolution XP spectra in Gaia DR3.
Deokkeun An, Timothy C. Beers, Anirudh Chiti   +2 more
doaj   +1 more source

Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation

Advanced Science, EarlyView.
Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater, Savvas Kourtis, Camilla Reiter Elbæk, Lorena Espinar, Carolina Toro‐Márquez, Albert Coll‐Manzano, Alfredo Smiriglia, Laura García‐López, Laura Wiegand, Maria Guirola, Frédéric Fontaine, Andrea Morandi, André C. Müller, Sara Sdelci   +13 more
wiley   +1 more source

IL‐3 Modulates Microglia Polarization and Attenuates Neuroinflammation in Traumatic Brain Injury

Advanced Science, EarlyView.
IL‐3 recruits PRDX1 through IL‐3R to modulate the inflammatory response of microglia via the KEAP1‐NRF2‐HO‐1/NF‐κB pathway to attenuate neuroinflammation in traumatic brain injury. ABSTRACT Microglia play a crucial role in the progression of neuroinflammation following traumatic brain injury (TBI). Interleukin‐3 (IL‐3), a significant regulatory factor,
Nana Huang, Qingchen Zhang, Yanrui Chen, Dapeng Yu, Ronghan Liu, Jianning Kang, Xiang Fang, Ying Zhang, Hong Bian, Yanxin Zhao, Yongcheng Yin, Ce Zhang, Yanfei Jia, Qingfa Chen, Yuepeng Fang, Shang Li, Fang Li, Zhengxin Jin, Bin Ning   +18 more
wiley   +1 more source

Molecular Gas Morphological Analogs for the Milky Way

The Astrophysical Journal Letters
Complete catalogs of molecular clouds in the Milky Way allow analysis of the molecular medium and the star formation properties of the Milky Way that closely follows the method used for nearby galaxies.
Neal J. Evans II, Davide Elia, Keith Hawkins, Sophia Stuber, Jiayi Sun   +4 more
doaj   +1 more source

GSH‐Responsive Nanoparticles Enhance Hepatocellular Carcinoma Immunotherapy Through Synergistic Effects of Cuproptosis and PI3K Inhibitor Combination

Advanced Science, EarlyView.
ABSTRACT Cuproptosis, an emerging form of programmed cell death, is capable of inducing mitochondrial dysfunction. Moreover, the PI3K‐AKT‐mTOR signaling pathway contributes to tumor cell progression by reprogramming mitochondrial morphology and function.
Lei Wu, Jintong Na, Xiyu Liu, Dongsheng Tang, Zhungang Yang, Zheng Cao, Xinyue He, Haihua Xiao, Liping Zhong, Yuan Liao, Yongxiang Zhao   +10 more
wiley   +1 more source

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

When the Milky Way hosted a quasar

, 2022
Marin F, Churazov E, Khabibullin I, Ferrazzoli R, Gesu LD, Barnouin T, Marco AD, Middei R, Vikhlinin A, Costa E, Soffitta P, Muleri F, Sunyaev R, Forman W, Kraft R, Bianchi S, Donnarumma I, Petrucci P, Enoto T, Agudo I, Antonelli L, Bachetti M, Baldini L, Baumgartner W, Bellazzini R, Bongiorno S, Bonino R, Brez A, Bucciantini N, Capitanio F, Castellano S, Cavazzuti E, Chen C, Ciprini S, De Rosa A, Monte ED, Lalla ND, Doroshenko V, Dovciak M, Ehlert S, Evangelista Y, Fabiani S, Garcia J, Gunji S, Hayashida K, Heyl J, Ingram A, Iwakiri W, Jorstad S, Kaaret P, Karas V, Kitaguchi T, Kolodziejczak J, Krawczynski H, Monaca FL, Latronico L, Liodakis I, Maldera S, Manfreda A, Marinucci A, Marscher A, Marshall H, Massaro F, Matt G, Mitsuishi I, Mizuno T, Negro M, Ng C, O'Dell S, Omodei N, Oppedisano C, Papitto A, Pavlov G, Peirson A, Perri M, Pesce-Rollins M, Pilia M, Possenti A, Poutanen J, Puccetti S, Ramsey B, Rankin J, Ratheesh A, Roberts O, Romani R, Sgro C, Slane P, Spandre G, Swartz D, Tamagawa T, Tavecchio F, Taverna R, Tawara Y, Tennant A, Thomas N, Tombesi F, Trois A, Tsygankov S, Turolla R, Vink J, Weisskopf M, Wu K, Xie F, Zane S.   +103 more
europepmc   +1 more source