Results 131 to 140 of about 134,673,186 (290)
Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis
Advanced Science, EarlyView.Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang +9 more
wiley +1 more source
The Astrophysical JournalUsing K giants from the second data release (DR2) of the Dark Energy Spectroscopic Instrument (DESI) Milky Way Survey, we measure the shape, orientation, radial profile, and density anisotropies of the Milky Way (MW) stellar halo over 8 kpc < r _GC < 200
Songting Li +47 more
doaj +1 more source
Whole-fat dairy products do not adversely affect adiposity or cardiometabolic risk factors in children in the Milky Way Study: a double-blind randomized controlled pilot study. [PDF]
Am J Clin Nutr, 2021 Nicholl A +7 more
europepmc +1 more source
A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation
Advanced Science, EarlyView.A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu +7 more
wiley +1 more source
, 1998 A flyby of the Milky Way galaxy showing an antimatter plume Educational levels: Undergraduate lower division, Undergraduate upper division, Graduate or ...
Alex Kekesi +2 more
core
Advanced Science, EarlyView.The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo +20 more
wiley +1 more source
Mapping the Milky Way in 5D with 170 Million Stars
The Astrophysical JournalWe present Augustus , a catalog of distance, extinction, and stellar parameter estimates for 170 million stars from 14 mag < r < 20 mag and with ∣ b ∣ > 10° drawing on a combination of optical to near-infrared photometry from Pan-STARRS, 2MASS, UKIDSS ...
Joshua S. Speagle +20 more
doaj +1 more source
Advanced Science, EarlyView.. ABSTRACT Neural presbycusis disrupts auditory timing and speech perception, yet its molecular basis remains poorly understood. This study identifies Cntn2 as the Ranvier's nodal molecule significantly downregulated in aged auditory nerves. Cntn2 heterozygous knockout (Cntn2+/−) mice showed elevated auditory brainstem response thresholds and prolonged
Penghui Chen +8 more
wiley +1 more source
The R-process Alliance: Enrichment of r-process Elements in a Simulated Milky Way–like Galaxy
The Astrophysical JournalWe study the formation of stars with varying amounts of heavy elements synthesized by the rapid neutron-capture process ( r -process) based on our detailed cosmological zoom-in simulation of a Milky Way–like galaxy with an N -body/smoothed particle ...
Yutaka Hirai +13 more
doaj +1 more source
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source