Results 111 to 120 of about 126,794,803 (294)
The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity
FEBS Open Bio, EarlyView.Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav +4 more
wiley +1 more source
Milky Way Sign in Progressive Multifocal Leukoencephalopathy. [PDF]
Ann Indian Acad Neurol, 2022 Agarwal A +4 more
europepmc +1 more source
MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
FEBS Open Bio, EarlyView.MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
Farthest neighbor: the distant Milky Way satellite Eridanus II*
, 2017 We present Magellan/IMACS spectroscopy of the recently discovered Milky Way satellite Eridanus II (Eri II). We identify 28 member stars in Eri II, from which we measure a systemic radial velocity of vhel=75.6 ±1.3(stat.) ±2.0(sys.) km s-1 and a velocity ...
Kathy Romer (4460893) +1 more
core
Plant-Based Dairy Alternatives-A Future Direction to the Milky Way. [PDF]
Foods, 2023 Plamada D +14 more
europepmc +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Inner Workings: Astronomers are redrawing our corner of the Milky Way. [PDF]
Proc Natl Acad Sci U S A, 2021 Croswell K.
europepmc +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
The masses of the Milky Way and Andromeda galaxies
, 2010 We present a family of robust tracer mass estimators to compute the enclosed mass of galaxy haloes from samples of discrete positional and kinematical data of tracers, such as halo stars, globular clusters and dwarf satellites.
Watkins, L.L. +5 more
core +1 more source